J. Liu

The paper analyzes genomic landscapes across a divergence gradient in Populus species to identify evolutionary forces shaping diversity and differentiation.

The paper uses the Cell Painting Assay to identify bioactive compounds in dark chemical matter, revealing modulators of microtubules, DNA synthesis, and pyrimidine biosynthesis.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

The paper uses cryo-electron tomography to study the folding landscape of an RNA origami 6-helix bundle, revealing multiple conformations and a possible folding pathway.

This study establishes a rat model of diminished ovarian reserve (DOR) combined with chronic unpredictable mild stress (CUMS) and finds that stress exacerbates ovarian dysfunction.

This study shows that diet-induced obesity disrupts chromatin oxygen sensing in macrophages, impairing hypoxia-induced glycolysis and efferocytosis.

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

This study identifies and characterizes bacterial P450 enzymes that catalyze post-translational macrocyclization of peptides, expanding the known functional capabilities of P450s.

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

This study investigates the role of cortical microtubules in Toxoplasma gondii motility, showing that their destabilization reduces helical movement without affecting speed or invasion/egress.

This study shows nano-silver inhibits and forskolin promotes rice seed germination through regulation of OsPIP2-1 and α-amylase.

This study identifies two enzymes, XL2 and XLH4, critical for lysophosphatidylcholine hydrolysis in Plasmodium falciparum-infected erythrocytes, revealing their role in fatty acid scavenging and parasite survival.

This study reprograms Geobacillus thermoglucosidasius to produce high-purity lactic acid at 60°C using rational and semi-rational design strategies, achieving high yield and productivity.

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

This study develops a human colon model to assess how C. difficile toxins affect epithelial cells from different sides, finding that basal exposure causes more severe toxicity.

This paper shows that Toxoplasma gondii infection changes dendritic cell durotaxis by altering F-actin structure and FAK phosphorylation, promoting parasite brain dissemination.

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study identifies and characterizes tat-fimbriae (tafi), novel haloarchaeal surface structures formed via the Tat-pathway, and demonstrates their synthesis in a heterologous host.

The paper identifies a luminal intermediate cell state in the prostate that maintains homeostasis and contributes to tumorigenesis in mouse models, with potential relevance to human prostate cancer.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

The paper identifies cGLRs as a widespread family of pattern recognition receptors in animal innate immunity and elucidates their conserved signaling mechanisms.

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

The paper introduces a pillar/perfusion plate for dynamic 3D cell culture, improving growth, reproducibility, throughput, and user friendliness compared to static methods.

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.