J. Liu

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

This paper identifies a viral ubiquitin deconjugase that modulates ribosomal stress responses and translation, enhancing viral production and contributing to EBV-related diseases.

This study uses a microphysiological system to show hypoxia primes human intestinal stem cells (hISCs) to respond to interleukins, enhancing their activity under hypoxic conditions.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study evaluates the durability of humoral and cellular immune responses to XBB.1.5 after bivalent mRNA boosters, finding waning neutralizing antibody titers but preserved T cell responses.

The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

The paper introduces an ex vivo model called 3MIC to study metastatic features in tumor cells under various metabolic conditions and stromal interactions, finding that extracellular acidification is more critical than hypoxia in promoting metastasis.

This study uses phylogenomic analysis to identify ancient hybridization and differential diversification as sources of phylogenetic conflict in Populus and Salix.

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

The paper shows that Lon protease DNA binding protects bacteria and mitochondria from genotoxic stress by clearing bound proteins.

This paper develops a biomimetic human lung alveolar interstitium chip that improves epithelial barrier function and extends longevity beyond eight weeks.

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

The paper evaluates optical genome mapping as a prenatal diagnostic tool, showing 100% concordance with standard methods across multiple sites and operators.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This study identifies the cellular origin of aberrant SALL4 expression in MDS using mass cytometry, showing it is mainly in HSPC and myeloid lineages, with SALL4/p53 co-expression linked to TP53 mutations.

This study identifies LjPup1 as a cytokinin exporter in root nodules that coordinates shoot growth with nitrogen fixation by exporting active cytokinins.

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

This paper describes an automated head-fixation training system that enables high animal participation in psychoacoustic tasks with efficient training sessions.

This study characterizes the developmental and evolutionary dynamics of chromatin states in Drosophila pseudoobscura, revealing how transposable elements contribute to genome organization and regulation across different stages and tissues.

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

This paper develops a method to independently control cell patterning and adhesion on hydrogels to study tissue interfaces and mechanobiology.

This study uses cleared tissue microscopy and machine learning to analyze 3D histopathology of biomaterial implants and their interaction with tissue microenvironments.

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.