J. Liu

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

This paper establishes a genetic sexing system for the fruit fly Ceratitis capitata using a sex-specific fluorescent marker, enabling accurate male-female separation without antibiotics or temperature dependence.

This study shows that replenishing IRAK-M in retinal pigment epithelium reduces outer retinal degeneration in age-related macular degeneration.

This study shows that influenza A virus suppresses progesterone in pregnant mice, leading to adverse maternal and fetal outcomes, which can be mitigated by progestin treatment.

This study identifies pyruvate as an inhibitor of cPLA2 that reduces obesity and inflammation in mice by targeting this enzyme, suggesting its potential as a therapeutic agent.

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

The paper identifies critical antiviral residues in IFN subtypes and designs improved IFN molecules with enhanced antiviral activity against HIV and HBV.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

This study examines microbial traits involved in B12 biosynthesis in the global ocean, revealing that environmental factors select functional traits over taxonomy and that functional redundancy drives community assembly.

This study evaluates Yaq-001, a non-absorbable carbon bead, in rodent cirrhosis and ACLF models, showing improvements in inflammation, liver function, and microbiome composition.

This study identifies isoDGR-damaged proteins as contributors to age-related lung pathology and shows that anti-isoDGR antibodies reduce lung damage in mice.

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

This paper develops a model to predict the tension-dependent lifetime of Tension Gauge Tethers (TGTs) and validates it with experimental data.

The paper determines the atomic structures of two distinct archaeal type IV pili formed by the same pilin under different growth conditions, revealing structural flexibility and conformational diversity.

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

The paper shows ice nucleation proteins self-assemble into fibres that trigger freezing near 0 ℃ by forming multimers essential for frost formation.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This study examines how biodiversity conservation policies address mining threats, finding limited inclusion in national targets and superficial treatment, and proposes an 8-point strategy to mitigate biodiversity impacts of construction minerals.

SNP-Slice resolves mixed infections by inferring strain haplotypes and linking them to hosts from polygenomic data, outperforming existing methods in accuracy and utility.

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

This study evaluates the synergistic effect of tigecycline with apramycin and amikacin against tet(X)-harboring Acinetobacter spp., finding significant synergy with apramycin.