J. Shi

The paper develops GenEPi, a fluorescent reporter for visualizing mechanical stimuli based on Piezo1, demonstrating high specificity and spatiotemporal resolution in live tissues.

This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.

This study investigates lipid interactions of PC2 using simulations and cryo-EM, identifying PIP and cholesterol binding sites.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study examines genome damage in rice and maize after biolistic transformation, finding that some events result in large-scale chromosomal alterations and repair via homology-dependent mechanisms.

The paper introduces TAP, a tool that identifies developability issues in therapeutic antibodies using five computational guidelines based on structural and charge properties.

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

This study identifies HNF1A as a central regulator of pancreatic cancer stem cells and a novel oncogene in pancreatic ductal adenocarcinoma.

The paper uses cryo-ET to study nucleosome organization in fission yeast mitotic chromosomes, revealing cluster and megacomplex structures and explaining gene expression patterns during mitosis.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.

This study investigates the structure of natural chromatin in vitro using cryo-ET, showing it forms compact masses with rare 30-nm fibers and is sensitive to divalent cations and histone modifications.

The paper presents uncharacterized bacterial structures observed via electron cryotomography to encourage their identification and study.

This study identifies 916 differentially expressed genes in rat cells over-expressing U1 snRNA, with 12 enriched pathways linked to cancer.