J. Sun

This study links VDR regulation of Claudin-5 to intestinal barrier function and tumorigenesis in colorectal cancer, showing VDR deficiency reduces Claudin-5 and increases tumor formation.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This study shows that bacterial colony chirality is linked to cell filamentation and division regulation, not single-cell twisting.

This study identifies two new Asgardarchaeota lineages with methylotrophic metabolism enhanced by genetic code expansions, including selenocysteine and pyrrolysine recoding.

This study investigates the effect of aldosterone excess on the epoxyeicosatrienoic acid (EET) pathway in endothelial and smooth muscle cells, finding no significant changes in gene expression or EET release.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

This study uses post-translational knockdown and post-secretional inhibition of EsxA to confirm its membrane-permeabilizing activity is essential for mycobacterial virulence without confounding genetic compensation effects.

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

This study evaluates SARS-CoV-2 entry mediated by ACE2 from 11 species, finding that pangolin and some mammals allow entry, while others do not, suggesting complex cross-species transmission potential.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

This study shows metformin reduces high glucose-induced endothelial ROS through the AMPKα-Lin-28-OGG1 pathway in HUVECs and diabetic mice.

This study shows that aged hosts experience chronic lung inflammation and fibrosis after viral pneumonia due to dysfunctional CD8+ tissue-resident memory T cells.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

This study identifies PAINT as an oncogenic lncRNA in prostate cancer that promotes progression by regulating EMT, apoptosis, and drug resistance.

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

This study uses single-cell RNA sequencing to identify silkworm hemocyte subsets and analyze their response to BmNPV infection, revealing diverse gene expression changes and immune suppression.

This study shows EsxA is internalized into host cells and inserts into host membranes, and surface-associated EsxAB enhances mycobacterial adherence and invasion.

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

The paper investigates the genomic basis of symbiosis in a vent snail, revealing a tripartite holobiont system involving host, endosymbionts, and gut microbiota, highlighting metabolic flexibility and mutualistic interactions.

This study contrasts the population structure and demographic history of two cereal aphid species in different agricultural landscapes, revealing distinct genetic patterns and potential responses to human-induced environmental changes.