J. Sun

This paper develops an in vitro transcription system for C. elegans using nuclear extracts and validates it for studying pathogen effects on transcription.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study characterizes the transcriptomic response of a recently formed triploid plant species to submergence, revealing inherited traits from its parental species.

This study shows that liver-specific ANGPTL4 suppression improves obesity-related diabetes and reduces atherosclerosis in mice by enhancing lipid metabolism and reducing inflammation.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

This study predicts lncRNA-encoded small peptides in glioma and analyzes their oligomer channel function using in silico methods.

This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.

The paper shows that monounsaturated fatty acids (MUFA) are essential for B cell function and humoral immunity, with SCD-mediated MUFA production supporting early B cell development and germinal center formation.

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

This study shows that EsxA's cytolytic activity at neutral pH is due to ASB-14 contamination, and EsxA inserts into host membranes in acidic compartments, supporting its role in Mtb virulence.

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

This study investigates how TSG-6 affects BMP-4/Smad signaling and odonto/osteogenic differentiation of DPSCs in an inflammatory environment.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

This study sequenced and analyzed the transcriptome of Rana chensinensis to identify genes associated with polyunsaturated fatty acid synthesis.

The paper reconstructs genomes of Undinarchaeota, a new DPANN archaeal lineage, and analyzes their phylogenetic placement and potential gene exchange with hosts.

This study investigates lung inflammation and endothelial dysfunction in severe Orientia tsutsugamushi infection, identifying biomarkers of vascular disruption and M1-skewed inflammation.

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

This study shows that intestinal VDR protects against dysbiosis and tumorigenesis by modulating the JAK/STAT pathway through microbiome interactions.

This study shows NUP153 links nuclear pore complexes to chromatin structure by mediating CTCF and cohesin binding at regulatory elements and TAD boundaries, affecting gene expression and transcriptional activation.

The paper uses single cell proteomic analysis to identify distinct signaling phenotypes in gliomaspheres, revealing EGFR and AKT/TORC1 signaling divergence and potential therapeutic targets.

This study shows that Nα-acetylation of Thr2 on EsxA is necessary for its dissociation from EsxB and subsequent mycobacterial virulence.

This study examines how wrinkle structures in the veins of Asian ladybird hind wings affect deformation and flight performance, suggesting bioinspiration for micro air vehicle wing design.

This study identifies IRAK1-mediated supramolecular organizing centers that coordinate multiple immune pathways to license inflammasome activation in response to microbial signals.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.