J. Tan

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.

The paper identifies and validates 25 putative genomic safe harbour loci for transgene integration in human cells using computational analysis and in vitro experiments.

This study shows that extrinsic motivators increase children's cooperation in forest conservation games across three countries.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

The paper links microbial community composition to environmental redox conditions using 16S rRNA gene data and predicted proteomes, showing redox gradients in hydrothermal systems and shale gas wells.

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

This study identifies SNHG1 as a regulator of LPS-induced acute lung injury by modulating the miR-421/TIMP3 axis in A549 cells.

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

This study compares dog and wolf puppies to show domestication enhanced dogs' cooperative communication with humans through increased attraction to humans.

The paper shows dietary protein increases sIgA via gut microbiota-derived extracellular vesicles, independent of T cell pathways or microbiota composition.

The paper describes a low-cost cell stretcher device that reveals density-dependent mechanical regulation of collective cell movements in epithelia.

The paper shows that the m.3243A>G mtDNA mutation activates the PI3K-Akt-mTORC1 pathway, which can be inhibited to reduce mutant mtDNA load and improve cellular function.

This paper shows that targeted e-learning for larger classes reduces student mixing and disease transmission while maintaining most in-class learning during a pandemic.

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

This study introduces HRnV, a new measure of heart rate variability, and shows it improves risk prediction for adverse cardiac events in chest pain ED patients compared to traditional scores.

The paper analyzes protein composition trends in metagenomes across redox and salinity gradients, finding that salinity affects hydration states while redox gradients are better captured by carbon oxidation state differences.

The paper develops and applies FLIM probes to measure Abl and Src-family kinase activities in live cells without FRET or genetic encoding.

The paper shows PCV2 worsens SS2 infection in PK15 cells through differentially expressed proteins and pathway analysis.

The paper profiles miRNAs and uses degradome sequencing to study their role in CMS regulation during anther development in pepper, identifying differentially expressed miRNAs and their target transcripts.

The paper introduces a deep learning method to predict virus hosts using DNA sequences, applied to 2019-nCoV to identify potential hosts like bats and minks.

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

This paper shows that the bacterial T6SS effector EvpP inhibits neutrophil recruitment by suppressing Jnk-Caspy inflammasome signaling in zebrafish larvae during infection.

This study examines how ZIKV infection during different pregnancy trimesters affects placental immune and transcriptomic responses, identifying unique molecular changes associated with early infection.

This study differentiates urine-derived induced pluripotent stem cells from a diabetic patient into neuron, astrocyte, and microvascular endothelial cells to create an in vitro disease model for studying diabetes-related CNS complications.

This study identifies iRhom2 as a key regulator that promotes obesity-associated metabolic disorder by enhancing adipose inflammation and insulin resistance.

The paper investigates how praying mantises perceive motion-in-depth during prey capture, finding that they use looming cues rather than stereo cues for this task.

This paper develops a method to consistently measure Fj and Fi in PSII chlorophyll fluorescence induction by tracking curvature, improving accuracy under varying conditions.