J. Zhang

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

The paper shows C/EBPα binds RNA via novel domains, recruits to enhancer sites, and promotes Macrophage differentiation by regulating PU.1 expression.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

This study identifies the role of Efnb2-Ephb4-Rasa1 in repressing MAPK/Erk signaling to regulate lymphatic valve formation and suggests potential therapeutic targets.

This study shows that gp130/STAT3 signaling is essential for chondrocyte proliferation and anabolism, with loss leading to growth defects and cartilage dysfunction.

This study shows GRASP55 promotes mutant huntingtin secretion via autophagy and stress conditions, reducing aggregation and toxicity.

The paper identifies a Klebsiella strain from the gut of Spodoptera frugiperda larvae that degrades PVC, using multi-omics to characterize the degradation pathway.

This study shows macaque monkeys use strategy-based hierarchical decision-making to play Pac-Man with over 90% accuracy, revealing advanced cognitive capabilities previously unobserved in animals.

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

This study identifies PTPN14 as a stabilizer of SMAD4, enhancing BMP9 signaling in endothelial cells and suggesting potential drug targets for HHT.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study shows that nutrient metabolism and ER redox homeostasis regulate insulin granule formation in pancreatic β-cells, linking glucose metabolism to proinsulin export and T2D pathogenesis.

This study examines cardiotoxic effects of methamphetamine in zebrafish, finding increased heart rate but not QTc prolongation, along with myocardial damage and gene expression changes.

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

This study identifies 21 new biomarkers in Caucasian American women with triple-negative breast cancer by analyzing the CmP signaling network under mPR-specific steroid actions.

This study shows that suppressing Chl a catabolism in ryegrass reduces heat tolerance by disrupting photosystem stability, ROS balance, and chloroplast structure under moderate heat stress.

This paper develops a microelectrode array system for real-time ECG and EEG monitoring in Xenopus laevis under chemical exposure, demonstrating its ability to detect drug-induced physiological changes.

This study identifies Tert+ acinar cells as critical for pancreatic regeneration, showing their activation by Yap/Taz and their role in tissue repair.

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

The paper identifies Lsm12 as an NAADP receptor and TPC regulatory protein essential for Ca2+ mobilization from acidic organelles.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

This study identifies WAPO-A1 as the causal gene for a QTL affecting spikelet number per spike in wheat and shows that the H2 haplotype significantly increases grain yield.

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

The paper identifies clonally expanded cytolytic memory CD4+ T cells in Plasmodium falciparum malaria patients and links their reduced chemotactic and inhibitory receptor expression to clinical immunity.

This paper engineers HIV-1 envelope trimers with enhanced V2 and fusion peptide neutralization sensitivity for vaccine development.