J. Zhang

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

The paper investigates P2X7 receptor expression in the gut nervous system, finding it primarily in macrophages and glia rather than neurons, and suggests these cells mediate P2X7 effects in IBD.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This study compares the replication efficiency of SARS-CoV-2 Omicron with earlier variants in human airway and alveolar epithelial cells, finding higher replication in airways and reduced replication in alveolar type 2 cells.

The paper analyzes the expansion and adaptive evolution of mTERF genes in plants, finding that M-class mTERF genes expanded via tandem duplication and evolved rapidly with positive selection in nucleic acid-binding sites.

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

The paper demonstrates mating between haploid cells with human GPCRs and enables hGPCR signaling in probiotic yeast using transcriptome analysis and ligand-free screening.

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

This study examines nitrate-dependent Fe(II) and As(III) oxidation by Acidovorax sp. strain ST3, identifying Fe(III) minerals and their As immobilization capabilities.

The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study analyzes the impact of socio-economic factors on surface water quality at provincial boundaries in China, identifying key factors affecting water quality.

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

This study shows that air pollution particles promote lung cancer by hijacking peroxidasin to alter collagen crosslinking, impairing immune surveillance.

This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.

This study shows that human intestinal epithelial cells use caspase-1/4-dependent inflammasomes, not NAIP/NLRC4 or NLRP3/ASC, to respond to Salmonella Typhimurium.

This study identifies CFAP61 as essential for sperm flagellum formation and male fertility in humans and mice, showing its role in axoneme stabilization and its mutation causing infertility.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study shows that traumatic brain injury (TBI) rapidly induces splenic dendritic cell maturation via FLT3/FLT3L signaling, which is enhanced by ethanol intoxication.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

BCM3D 2.0 improves 3D bacterial cell segmentation in dense biofilms by using intermediate image representations generated by CNNs, enhancing accuracy even at low signal-to-background ratios.

The paper uses multimodal imaging and single nuclei RNA-sequencing to study how type I interferon affects viral tropism in the brain during flavivirus infection in mice.

This study reveals how PLN mutations reduce phosphorylation by altering conformation and PKA interactions, contributing to DCM.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies genetic and epigenetic variations associated with the rapid radiation of Aquilegia species by analyzing genomes and methylomes across three lineages.