J. Zhang

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

This paper identifies cell behaviors driving aggregate dispersal in Myxococcus xanthus using microscopy and modeling, showing reversal bias changes correlate with aggregate size and genetic control.

This paper develops a co-culture platform to create photosynthetic living fibers using algal-bacterial consortia with controlled spatial distribution for bioremediation and advanced materials.

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

The paper develops new ATP biosensors with improved dynamic range and signal-to-noise ratio for subcellular and multiplexed imaging in live cells.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

This study identifies a monocyte-intrinsic TNF-IL-1 circuit that controls Yersinia infection within intestinal granulomas by signaling to non-hematopoietic cells.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

This study identifies SUMOylation defects in Aspergillus nidulans leading to chromatin bridges during mitosis without affecting dynein function.

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.

This study shows that ferroptosis contributes to TMJOA cartilage degradation and that Lip-1 inhibits this process by reducing ferroptosis markers and oxidative stress in chondrocytes.

The paper develops a theoretical model to study coevolution of mRNA and protein levels, finding that stabilizing selection leads to compensatory evolution, while directional selection causes negative correlation across lineages and positive correlation across genes.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

This study shows that PIEZO1-mediated mechanosensing affects NK cell killing efficiency and infiltration in 3D matrices by responding to tumor cell stiffness.

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

This paper introduces a new multimodal optical imaging technique combining Brillouin and photoacoustic microscopy to measure mechanical, optical, and acoustical properties of biological samples with high resolution.

This study identifies the ABI3-ERF1 module as a key mediator of ABA-auxin crosstalk in regulating lateral root emergence in Arabidopsis.

The paper evaluates deep learning methods for molecular conformation generation by comparing them to a stochastic 'infinite physical monkey' approach, finding that the monkey method outperforms most DL-based methods in coverage and docking success.

This study identifies diagnostic SNPs for FOV4 resistance in Upland cotton and finds that specific SNP genotypes correlate with reduced vascular discoloration.