J. Zhang

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.

The paper identifies 647 prognostic and diagnostic biomarkers for hepatocellular carcinoma (HCC) using transcriptomic data and machine learning, offering potential for improved diagnosis and treatment.

This study shows FDX1 is essential for embryonic development and lipid homeostasis, with knockout mice showing embryonic lethality and lipid droplet accumulation.

The paper identifies ascertainment bias in a genomic test for positive selection on regulatory sequences and proposes methods to mitigate it.

This study shows that local CpG-Stat3 siRNA treatment enhances checkpoint inhibitor efficacy in mouse tumor models by improving T-cell responses.

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

This study investigates the co-evolution of feeding organs in early elephantiforms, finding that feeding function shifted from the mandible to the trunk, enabling proboscideans to expand into new ecological niches.

This study investigates the structure and function of the human MRS2 channel, revealing its Ca2+-regulated, non-selective ion permeability and a conserved arginine ring that prevents proton motive force collapse.

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

This paper develops SHRIMP, a genetically encoded red fluorescent hydrogen peroxide sensor with high brightness and minimal photoactivation, validated in mammalian cells and primary islet tissue.

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

This paper introduces tDKI to map cellular pathology in brain ischemia, showing it detects changes in cell morphology and membrane permeability in vivo.

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

This study identifies bZIPC1 as a wheat transcription factor interacting with FT2, affecting spikelet and grain number per spike, and discovers a favorable natural allele for breeding.

This paper develops a genetically encoded red fluorescent UDP-GlcNAc biosensor using a boronolectin and validates its function in live cells.

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

The paper identifies TDIF ligand-activated PXY receptors and CAIL transcription factors as key to defining cambium stem cell identity in Arabidopsis roots and explains their positioning mechanism.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

The paper uses FRET to study CaM conformational changes on RyR in skeletal and cardiac muscle, finding CaM becomes more compact at high Ca2+ and showing isoform-specific differences.

The paper reports the crystal structure of MEILB2-BRME1 complex and shows how BRCA2 binding causes it to form a V-shaped DNA clamp to facilitate meiotic recombination.

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

This study uses single-cell RNA sequencing and spatial transcriptomics to characterize the muscle microenvironment in PAD, identifying altered endothelial diversity and LYVE1+ macrophage activation.

The paper introduces a Transformer-based method for sEMG signal analysis to improve movement recognition accuracy and generalization across datasets.

The paper shows that actin-TFII-IΔ modulates ERK activity through cell height to direct cell fate during reprogramming.

This study investigates the effects of repeated methamphetamine exposure on zebrafish cardiac function, revealing decreased heart rate, increased heart rate variability, and fibrotic changes.

This study links methylation dynamics to maximum lifespan in mammals by showing a reciprocal relationship between methylation change rates and lifespan across species.

T-FINDER identifies T cell epitopes and their cognate receptors by analyzing HLA-presented peptides, demonstrating its utility in multiple diseases.