J. Zhang

This study shows that HORMAD proteins bind chromatin to regulate meiotic recombination initiation in yeast.

This study uses E. coli outer membrane vesicles to deliver target proteins into eukaryotic cells with high efficiency and enables direct labeling of proteins within vesicles.

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

The paper inserts four amino acids from lamprey CR1 into elephant shark MR and GR to test if their absence reduces steroid transcriptional activation, finding that the insert decreases activation.

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

This study identifies three novel chuviruses as the cause of lymphocytic meningoencephalomyelitis in three aquatic turtles, providing the first in situ evidence of chuviral pathogenicity in animals.

This study shows that exosomal CXCL1 from dying breast cancer cells promotes metastasis by activating TAM/PD-L1 signaling and identifies TPCA-1 as a potential inhibitor.

This study identifies the transsulfuration pathway as a targetable metabolic driver of glioblastoma invasion through multi-omic analyses of engineered biomaterials and patient biopsies.

The paper investigates the effect of PFAS pollution on AIV infection risk in three bird species, finding no significant association but suggesting further research is needed.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.

This study compares pollutant exposure, health, and survival of migratory shorebirds in natural and artificial wetlands, finding negligible differences and suggesting wastewater treatment plants could serve as viable habitats.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

The paper presents crystal structures of cis-acyltransferase (cis-AT) modular polyketide synthases (PKSs) to elucidate domain-domain interactions and reaction chamber organization.

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

This study shows Yersinia pseudotuberculosis effectors evade the caspase-4 inflammasome in human cells, unlike in mouse macrophages, by inhibiting Yersinia internalization.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

The paper presents the cryo-EM structure of BoNT/X-NTNH/X complex and shows its stability and low potency due to weak receptor-binding properties.

This paper identifies and characterizes the gene PLATZ-A1 underlying the GA-sensitive dwarfing locus RHT25 in wheat, showing it interacts with RHT1 and can modulate plant height.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

The paper examines spatial patterns of PAG activity and physiological responses during social stress in humans using 7T imaging.