L. Li

RapidAIM 2.0 evaluates gut microbiome functional responses to xenobiotics using high-throughput metaproteomics and in vitro culturing.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study identifies early metabolic dysregulation in a mouse arthritis model through integrative metabolomics and RNA-seq, highlighting the SIRT1 axis as a potential therapeutic target.

This study shows UPF3A is not required for NMD in mouse pluripotent and somatic cells, and may only weakly promote NMD in some tissues.

This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

This study develops recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens, showing they react strongly with human and rabbit sera and are promising for diagnostics and therapeutics.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This paper analyzes whether deep learning models in histopathology learn trustworthy or deceptive strategies, finding that some recent advances in molecular profiling from H&E slides are unreliable.

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.

The paper uses prenylomic analysis in AD mice to identify 36 prenylated proteins, with 15 showing increased levels, suggesting potential therapeutic targets.

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.

This study compares two Bifidobacterium pseudolongum strains to determine strain-specific effects on gut microbiota and host immune responses.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

This study develops a FLIM biosensor using merocyanine dyes to detect conformational changes in Cdc42, showing improved sensitivity at low activation levels compared to FRET-based methods.

The paper uses proteomics to compare immune responses to Salmonella Typhimurium infection in two mouse strains, identifying differentially expressed proteins and pathways involved in resistance.

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.