L. Ma

This study shows that inhibiting VTA dopamine neurons reduces risky decision-making and impulsivity in male rats but increases risky choices in females, while also reducing cocaine-induced decision-making deficits but increasing cocaine consumption.

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

This paper generates human stem cell models of CLN2 disease by introducing pathogenic TPP1 mutations using CRISPR/Cas9 and validates their reduced TPP1 enzyme activity.

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

This study compares the urinary microbiome in postmenopausal women with and without recurrent UTIs, finding no significant differences in Lactobacillus abundance but identifying anaerobic taxa differences associated with UTI recurrence.

The paper introduces CRISPIE, a CRISPR-based method for precise, efficient, and reversible labeling of endogenous proteins by inserting designer exons into target genes.

BiTSC2 jointly analyzes single-cell SNV and CNA data to infer tumor clonal trees with high accuracy and robustness to low sequencing depth.

This study compares how intracellular pH regulates ICRAC currents mediated by Orai1, Orai2, and Orai3 channels in HEK293T cells.

This study evaluates the toxicity, tumor colonization, and genetic stability of Salmonella enterica serovar Typhimurium CRC2631 in a TRAMP prostate cancer model and shows its potential for cancer immunotherapy.

This study identifies a novel oxidase in Alcaligenes sp. HO-1 that converts hydroxylamine to N2, revealing a previously unknown enzymatic pathway for nitrogen cycling.

This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.

The paper identifies a potent neutralizing nanobody against SARS-CoV-2 with high activity and stability for inhaled delivery.

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

This study shows that high levels of circulating mitochondrial DNA predict severe illness and mortality in COVID-19 patients.

The paper sequenced genomes of Pneumocystis species from different mammals to study host specificity and evolutionary adaptations, revealing insights into the emergence of the human pathogen P. jirovecii.

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

The paper develops a computational pipeline to identify microbial reads in scRNA-seq data and finds that microbial reads are enriched in myeloid cells with proinflammatory transcriptional changes.

This paper demonstrates that enzyme nanoclusters can depolymerize polyesters via chain-end mediated processive degradation, enabling scalable bioactive plastics for efficient sorting.

This study identifies autotransporters as key drivers of biofilm formation and auto-aggregation in Veillonella parvula using genetic tools and functional analyses.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

The paper shows that autophagy in lung epithelial cells enhances the production of antimicrobial peptides hBD1 and LL37, which kill intracellular Mycobacterium tuberculosis.

This study identifies a novel RecJ from Bacillus alcalophilus with endonuclease activity, distinct from previously known exonucleases, and highlights its potential as a gene editing tool.

This study investigates microbial mediation of anaerobic pyrite oxidation under circumneutral conditions and identifies ligand production as a preferred pathway over acidic micro-environments.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

This paper solves the crystal structure of the giant panda MHC class I complex, revealing unique features of viral peptide presentation in the bear family and providing insights for vaccine design.