L. Wang

This study shows that dry heat decontaminates N95 respirators and preserves their fit, unlike autoclaving which compromises fit and makes them unusable.

This study identifies H2B.8 as a histone variant that mediates chromatin condensation in flowering plant sperm through phase separation, enabling nuclear compaction without transcriptional inhibition.

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

This study identifies SlSWEET5b as a hexose transporter essential for pollen maturation in tomato by facilitating sugar translocation from phloem to anther cells and pollen.

This study shows HSV-1 infection releases cGAS from chromatin into the nucleus, where it senses viral DNA and activates type I IFN production.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

mRNA-1273 boosted nonhuman primates show increased neutralizing antibody responses and protection against SARS-CoV-2 beta variant infection.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

Four key regulators confer lignin accumulation in the tomato stem cortex to block C. campestris host penetration upon infection.

This study investigates neophobia in 10 corvid species, finding species differences and socio-ecological influences on novelty responses across 241 subjects in 10 labs.

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

The paper identifies TGF-β-dependent differentiation of stem-like CD8+ T cells into tissue-resident memory T cells in tumor draining lymph nodes, which negatively correlates with tumor vaccine response.

This paper models oncolytic viral therapy interactions to identify thresholds for treatment success and tumor reduction based on viral dynamics and virulence.

This study identifies conserved osmotic stress pathways in green algae and plants using transcriptomics and functional genomics, revealing a novel actin remodeling mechanism.

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

This study identifies novel apelin-expressing gCap endothelial stem-like cells that drive lung microvascular repair after endothelial cell ablation by apelin signaling.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The paper analyzes the solvent-excluded surfaces and atomic partial charges of water-soluble proteins, revealing a multilayered organization that optimizes protein-solvent interactions.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This study uses BioID and BioSITe to map TNK2's interactome, identifying known and novel binding partners and validating one with immunoblot.

This study determines the crystal and cryoEM structures of ALC1 and its nucleosome-bound form, revealing the autoinhibition mechanism and activation by the nucleosome.

This study identifies RBP45D as an RNA-binding protein involved in DCL3-independent RNA-directed DNA methylation and flowering time regulation in Arabidopsis.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.