L. Wang

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study shows STEAP1 can support a cross-membrane electron transfer chain via FAD, and determines the structure of STEAP2 in complex with NADP+ and FAD.

A single-shot ChAd3-MARV vaccine provided rapid and durable protection against lethal Marburg virus infection in macaques, with antigen-specific antibodies correlating strongly with immunity.

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

This study investigates how salt stress affects oil palm by analyzing gene expression and stomatal development, finding that EgSPCH promotes stomatal increase which aids in salt tolerance.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study identifies a compound, Dwn1, that downregulates Npas2 and accelerates wound healing with reduced scarring in mice.

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

This study identifies MAPK-associated phosphorylation sites in RSG that regulate its subcellular localization and function in tobacco.

This study integrates DNA methylome and transcriptome data from Salmonella Typhimurium under different conditions, finding that DNA methylation is largely static and only rarely correlates with gene expression changes.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

This study shows that mRNA-1273 vaccine protection against SARS-CoV-2 Delta in nonhuman primates persists for one year but is delayed and relies on anamnestic antibody responses in the lower airway.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

The paper identifies that combining indisulam with palbociclib enhances senescence in cancer cells by inhibiting CDK2 kinase activity.

The paper develops a minimal-invasive neural interface using MXene nanosheets to promote nerve regeneration and electrophysiology recording in mice.

This study shows that gp130/STAT3 signaling is essential for chondrocyte proliferation and anabolism, with loss leading to growth defects and cartilage dysfunction.

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

This study evaluates the effectiveness of high-energy electron beam irradiation in deactivating SARS-CoV-2 surrogate virus PEDV under cold chain conditions.

This study determines the cryo-EM structure of human ATAD1 with a peptide substrate, revealing conserved structural elements that enable its function in extracting mislocalized membrane proteins.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This paper reports cryo-EM structures of human ABCD1 in different states to elucidate its mechanism of substrate recognition, translocation, and release.