L. Wu

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This study identifies TRAF6 and TAK1 as mediators of SAMHD1's suppression of NF-κB activation and HIV-1 infection.

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.

The paper uses single-cell multi-omics to analyze HCC cell lines, identifying metastasis potential heterogeneity and a hypoxic subgroup with poor prognosis.

The paper examines how alanine substitutions in the HIV-1 Env FPPR region affect trimer conformation and epitope exposure, revealing weak antibody pressures shaping Env evolution.

The paper identifies catechol-containing compounds as broad amyloid inhibitors and shows redox state determines their activity.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

The paper examines how malaria transmission decline affects antimalarial IgG subclasses and avidity in Ugandans, finding age-related changes in IgG decay, subclass ratios, and avidity dynamics.

This study examines how different metabolic environments affect three cancer cell phenotypes: drug survival, migration, and lactate overflow, revealing quantitative relationships between metabolism and cell behavior.

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This paper develops CD19-targeting CAR T cells that secrete bridging proteins to enhance tumor targeting and cytotoxicity in solid tumors.

The paper analyzes CD45 isoforms in T cells from liver cancer patients to show their role in T cell heterogeneity and function.

This study identifies convergent genetic and physiological adaptations in multiple fish lineages that enable tolerance to hydrogen sulfide, showing that conserved mitochondrial pathways are repeatedly modified for H2S resistance.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

Inhibiting the prostaglandin transporter PGT reduces body fat and induces UCP1-independent thermogenesis in mice on a high-fat diet.

This study evaluates rice wild relatives for traits to improve adaptation to iron toxicity and grain quality, finding some genotypes perform better than domesticated rice in specific stress conditions.

The paper identifies distinct ligand-directed plasma membrane signalsomes in Arabidopsis that drive biased signaling through compartmentation and different trafficking origins.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This paper introduces an AI model to design and fold alpha-helical proteins from amino acid sequences, achieving high accuracy and efficiency.

The paper shows that the RNF43-G659Vfs41 mutation is functional and not a driver mutation in tumorigenesis, but may be a passenger mutation in MLH1-downregulated tumors.

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.

This study identifies Girdin as an essential replication initiation factor in human cells, required for pre-RC assembly by recruiting Cdc6 to DNA origins.