L. Zhao

The paper shows that airborne viral transmission creates tight bottlenecks due to physical processes, with most infections caused by few viral particles.

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates how calcitriol and cholesterol translocate through H. pylori lipid membranes and their effects on water permeability using molecular dynamics simulations.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study investigates the origin, evolution, and structural properties of de novo genes in Drosophila, finding that many produce well-folded proteins and show functional shifts over time.

This paper identifies microbiome features distinguishing three patient clusters with abnormal glycometabolism, stratified using unsupervised clustering of clinical parameters.

This study experimentally characterizes human gut mucus viscoelasticity and develops a model to study nanoparticle dynamics influenced by mucin cross-linking and concentration.

This study identifies 58 K. pneumoniae genes critical for bloodstream fitness during bacteremia, revealing tissue-specific mechanisms and resistance to oxidative stress.

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

This study enhances nisin production and antimicrobial activity in Lactococcus lactis subsp. lactis through genetic modifications involving nisA, nisRK, and nisZ genes.

The paper shows that reducing ELK3 expression enhances BMPR2 signaling and improves pulmonary vascular cell function in pulmonary arterial hypertension.

This study shows that IL-17 overactivation in C. elegans reduces lifespan and stress tolerance by inhibiting a protective transcriptional network involving NHR-49 and MDT-15.

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

This study identifies PTPN1 as a regulator of BMPR2 signaling in PAH, showing its downregulation in PAH patients and link to endothelial dysfunction.

The paper introduces a method to quantify mRNA and protein at cellular and subcellular resolution in plants using whole-mount smFISH.

The paper investigates convergent evolution of floral fragrance in self-fertilizing Capsella species, finding shared compound changes and mutations affecting scent emission.

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

This study models ancient Eurasian selection landscapes and shows ancestry-specific genetic risk associations with modern phenotypes.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

The paper identifies sex-differentially variable genes across human tissues and links them to biological functions and disease, suggesting a genetic basis and evolutionary model for sex-specific expression variability.

This study shows that the time of Chlamydia infection affects genital tract microbiome dynamics, with more robust associations in the upper genital tract.

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.