M. Zhang

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study shows that deleting GCN5L1 in cardiomyocytes reduces cardiac functional decline in HFD mice by enhancing substrate flexibility and reducing oxidative damage.

This study uses internet search data to show seasonal variation in cancer recurrence queries, with peaks in early summer (northern hemisphere) and late summer (southern hemisphere).

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

This study identifies EccE1 as a critical membrane protein required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis, with deletion of eccE1 reducing levels of other ESX-1 components and attenuating bacterial virulence.

The paper investigates the association between epidermal green autofluorescence intensity and serum cytokine levels in LPS-exposed mice, finding significant correlations with multiple inflammatory and anti-inflammatory cytokines.

This study optimizes fertigation for greenhouse strawberries by identifying the optimal levels of N, P, K, and water to maximize yield and SSC/TA ratio.

This paper develops a STED system for 3D super-resolution imaging in living mice, achieving depths of 76 micrometers in brain tissue.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This study describes the sexual stage of Venturia effusa, demonstrating its heterothallic nature and recombination through experimental mating type pairing and ascospore progeny analysis.

This study develops WGA-pHRho, a fluorescent pH sensor to visualize proton fluxes on the extracellular surface of cells, showing correlation between pH changes and proton channel activity.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study identifies the BD2 domain of BRD4 as critical for EndoMT and vein graft neointima formation, suggesting it as a therapeutic target.

This study shows BRD2 and SREBP2 work together to increase sigma-2 receptor expression when cells lack cytosolic cholesterol.

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.

This study shows that inhibiting DOT1L reduces intimal hyperplasia in rat carotid arteries by lowering H3K79 methylation levels.

This paper investigates the biosynthesis of formycin A and pyrazofurin A, identifying key enzymes and pathways involved in their C-nucleoside scaffold construction.

This paper develops a hierarchical Bayesian model to detect linear temporal changes in antibiotic resistance by accounting for censored MIC data and non-resistant population trends.

The paper identifies specific target proteins bound by WW domain tandems of KIBRA and MAGI with high affinity and specificity, revealing new binding partners and mechanisms.

This study identifies grain maturity as the main factor affecting gene expression changes in maize inoculated with Aspergillus flavus, with side needle inoculation causing more fungal reads and aflatoxin production.

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

This study shows that PERK inhibition reduces restenosis and thrombosis in animal models, suggesting it as a potential therapeutic strategy for drug-eluting stents.

The paper identifies Dnmt3aos as a lncRNA regulating Dnmt3a expression and DNA methylation in macrophage polarization, revealing its role in modulating IFN-gamma expression.

This paper corrects spatially-variant optical aberrations in 3D single-molecule localization microscopy using a computational phase retrieval method with a vectorial PSF model.

This paper introduces TetTCR-Seq to link TCR sequences to their antigens in single cells and identifies neo-antigen-specific TCRs with no cross-reactivity.

This paper introduces Hessian-SMLM, a method to reduce pixel-dependent readout noise in sCMOS cameras for single-molecule localization microscopy, improving imaging time resolution.

This paper shows that transmural mean hoop stress of the aortic wall can be calculated from in vivo images using thin-walled models without needing patient-specific material properties or residual deformations.

The paper uses single-molecule tracking to show SctQ and SctL form stable cytosolic complexes, revealing dynamic regulatory mechanisms in type 3 secretion.