M. Zhang

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

This study shows that low-dose dioxin exposure during pregnancy and lactation in mice increases susceptibility to diet-induced obesity and diabetes later in life.

This study shows increased epidermal green autofluorescence in skin and nails of lung cancer patients and mice, suggesting it as a potential non-invasive diagnostic biomarker.

The paper develops a fluorescent biosensor for L-2-hydroxyglutarate (L-2-HG) using LhgR, a transcription factor that recognizes L-2-HG, and demonstrates its application in monitoring L-2-HG levels in bacterial and human cells.

This paper introduces a biomimetic system for culturing 3-D respiratory tissues under physiological strain and air-liquid interface conditions, showing improved cell distribution and density compared to static controls.

The paper identifies horizontal gene transfer of ligE-type GSTs from fungi to plants and a protozoan, showing high similarity and limited substitutions in transferred genes.

This study shows that reducing keratin 1 in B16-F10 melanoma cells causes cell death and increased oxidative stress, suggesting K1 as a potential therapeutic target.

This study compares metagenomic sequencing and qPCR for detecting influenza D virus in bovine samples, finding varying agreement rates between methods.

BCM3D improves segmentation and classification of bacterial cells in 3D biofilms using deep learning and mathematical analysis.

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

This study evaluates the virucidal activity and safety of Povidone-iodine in-situ gel formulations against SARS-CoV-2 in vitro and in vivo.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study characterizes the autoantibody landscape in metastatic castration-resistant prostate cancer using serum epitope repertoire analysis and identifies novel tumor-specific epitopes.

This study identifies a partnership between BRD4 and CEBPD that promotes inflammatory SMC state transition and CEBPD transcription in vascular disease.

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

This study investigates DNA methylation variation during maize domestication using WGS and WGBS, identifying DMRs linked to gene regulation and adaptation.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

This study investigates how angioplasty induces epigenomic changes in rats, revealing BRD4 and EZH2's roles in regulating neointimal hyperplasia through histone modifications.

This study identifies a conserved exZZU extension in ankyrins that enhances binding to beta-spectrins through structural interactions, but shows that direct binding does not determine pairing specificity.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

The paper profiles miRNAs and uses degradome sequencing to study their role in CMS regulation during anther development in pepper, identifying differentially expressed miRNAs and their target transcripts.

This study examines the effects of atrazine exposure on DNA methylation and gene expression in zebrafish, identifying specific genes and pathways affected by the herbicide.

This study shows that a diversified learning environment improves active avoidance learning and mitigates stress-induced learning impairments in animals.

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.