Q. Chen

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

This paper investigates the impact of 14 non-synonymous SNPs in HIV on viral fitness, finding that specific mutations in integrase and RNase H impair GagPol autoprocessing and replication.

This study shows that S100A8 and S100A9 subunits inhibit HIV replication in macrophages but not T cells, despite their role in SARS-CoV-2 infection.

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

This study compares inbreeding depression in maize and teosinte, finding greater depression in maize due to polygenic small-effect recessive variation and reduced large-effect variants after domestication.

The paper quantifies polymerized actin in fission yeast contractile rings and shows cofilin and type II myosins regulate actin dynamics during cytokinesis.

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

This paper presents a drug candidate, NANA-Me, that prevents and treats ADAA-based diseases caused by pathogenic anti-spike antibodies in COVID-19 and vaccines.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

This study identifies Pkd2p in fission yeast as promoting cell expansion during interphase and antagonizing the Hippo pathway SIN during cytokinesis.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

The paper identifies a lipid-mTORC1 pathway regulated by peroxisome-derived hormones that controls development in C. elegans by modulating chemosensory neurons.

This study identifies that ER-targeted mRNAs can be recruited into stress granules during the UPR and shows that transcriptional state influences SG formation.

This study investigates the antimicrobial synergy between ibuprofen and standard-of-care antibiotics against CF pathogens, showing in vitro and in vivo efficacy against drug-resistant strains.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

The paper develops an automated classifier to detect Hainan gibbon calls using deep learning, achieving high accuracy and reducing manual processing time.

C010DS-Zn induces parthanatos in cancer cells, triggering anti-tumor immune responses involving T cells and macrophages in vivo.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

This study compares long-term effects of grazing and mowing on plant diversity and community composition in salt marshes across spatial scales.

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This paper integrates crop growth and radiative transfer models with deep learning to improve the estimation of crop traits from hyperspectral data.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

The paper identifies calcium spikes during fission yeast cytokinesis and shows they promote contractile ring constriction and daughter cell integrity.

The paper investigates the effects of YAP1/TAZ transcriptional inhibition in cancer cells, revealing TEAD-dependent and independent roles in tumor proliferation and differentiation.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.