Q. Chen

The paper identifies a novel dermal migratory Langerhans-like cell population using fate mapping and single-cell RNA sequencing, showing distinct migration and replenishment characteristics compared to Langerhans cells.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

The paper identifies two distinct sinoatrial nodes in mammalian hearts, sSAN and iSAN, which control fast and slow heart rates under sympathetic and parasympathetic stimulation, respectively.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study identifies altered small RNA modifications in Alzheimer's disease post-mortem samples compared to controls, with specific reductions in certain small RNA types.

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper uses a mathematical model to show that Pf+ Pseudomonas aeruginosa strains can outcompete Pf- strains under specific antibiotic conditions, promoting antibiotic tolerance.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study identifies parasite variant surface antigens that help Plasmodium falciparum evade immune clearance in vivo using a humanized mouse model.

This study shows ethanol metabolism in the CeA to acetate activates NMDAR, causing sympathoexcitation in rats.

This paper develops a plant-made IgG fusion vaccine strategy that enhances antigen immunogenicity in mice without adjuvant, achieving 150-fold higher antibody titers than the antigen alone.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This study compares gene expression in the small intestine and colon of vitamin A deficient mice, identifying distinct transcriptional responses and novel VA-regulated genes.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The paper re-examines evidence for adaptive DNA sequence evolution using MK and PAML tests on Drosophila and Arabidopsis data, finding little overlap and suggesting unreliable results.

The paper investigates whether apparent signals of positive selection in DNA sequences are actually due to relaxed negative selection, finding strong fluctuations in negative selection strength across species.

This study examines trends in the human sex ratio at birth using electronic health records, finding no seasonal or temperature effects but associations between pollutants and lower sex ratios.

This study shows CDK1 phosphorylates CHMP7 during mitosis, preventing its interaction with LEM2 and suppressing ESCRT-III assembly until nuclear envelope reformation.

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.