S. Banerjee

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

This study isolates and characterizes a novel endo-xylanase-producing strain of Bacillus velezensis AG20 from a cave, demonstrating its enzymatic properties and prebiotic/anti-proliferative potential.

This study shows that IL-6 signaling protects zebrafish larvae from S. epidermidis infection by modulating inflammation and immune response.

This paper uses NMF on HD-sEMG signals to assess motor functional age across different age groups during STS tests, finding variations in muscle activation patterns with ageing.

This study examines age-related changes in the microbiome and systemic inflammation in Rhesus macaques, finding significant differences in microbial composition and metabolite profiles between young and old animals.

This study shows that modifying loop 1 residues in APOBEC3C enhances its antiviral activity against HIV-1 and LINE-1 by improving ssDNA binding and deamination.

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

The paper develops a kinetic theory to explain how multiple organelles regulate their sizes using a shared subunit pool, showing negative feedback ensures size control and positive feedback can lead to bistability and polarity.

Using a combination of mapping approaches, we identify interacting genes that lead to melanoma in hybrids and characterize their effects in natural hybrid populations.

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

This study shows that targeting the HBP metabolic node in pancreatic cancer with DON reduces tumor growth, remodels the ECM, and enhances response to anti-PD1 therapy.

This study examines gut microbiome differences in Sjögren’s disease patients compared to controls and finds associations between bacterial classes and dry eye symptoms.

This study shows GAS5 regulates quiescence and growth arrest in CD133+ cells, which drive tumor recurrence in pancreatic cancer by inhibiting cell cycle progression and altering metabolic pathways.

This study identifies DYRK2 as a kinase that phosphorylates HSF1, enhancing its activity and promoting resistance to proteotoxic stress in TNBC, with implications for therapeutic targeting.

This study shows that mechanosensitive tension remodelling of epithelial junctions enables robust shape changes through a ratcheting mechanism, using optogenetic control and a modified vertex model.

This study shows RhoA controls epithelial cell shape through mechanosensitive endocytosis, requiring formin and dynamin, and develops a vertex model to explain junction remodeling.

This paper evaluates the anti-leishmanial activity of Spergulin-A, a triterpenoid saponin from Glinus oppositifolius, showing potent intracellular efficacy against Leishmania donovani.

This study identifies a universal surface-to-volume scaling relation in rod-shaped bacteria, driven by aspect ratio homeostasis and a model linking cell elongation to FtsZ accumulation.

This study evaluates azaBINOL compounds as antiviral agents, identifying 7-isopropoxy-8-(naphth-1-yl)quinoline as a low-micromolar inhibitor of HIV-1 RNase H activity.

This study reports structures of APOBEC3B with loop 7 from APOBEC3G, revealing inactive conformations stabilized by small molecules, providing insights for inhibitor design.

This paper reports the crystal structure of Rv0081, a transcription factor in M. tuberculosis, and identifies key residues involved in hypoxic gene regulation through biochemical analysis.

The paper shows that reducing junctional tension increases tissue fluidity, which accelerates wound healing in epithelial tissues.

The paper examines how different farming systems affect wheat root fungal communities, finding that organic farming supports more complex fungal networks and higher abundance of keystone taxa.

The paper develops a molecular model explaining how surface interactions accelerate protein aggregation, validated through experiments with synuclein and APOBEC3G.

The paper introduces an Active Adherent Vertex Model to study how cell-scale dynamics influence traction stress distribution in epithelial colonies.

This study shows that O-GlcNAc modification of Sox2 stabilizes the protein and enhances self-renewal in pancreatic cancer, with targeting OGT reducing tumor burden.

This paper shows that a picornaviral 3CD protein induces multiple phospholipid biosynthetic pathways and membrane biogenesis by hijacking cellular machinery.

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.

The paper shows how filament rigidity and connectivity in active biopolymer networks affect deformation modes, contractility, and anisotropy through experiments and simulations.