S. He

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.

This study investigates how bacterial infection affects macronutrient consumption and immunity in Blatta orientalis cockroaches, finding limited immune benefits from dietary shifts.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This paper synthesizes global taxonomic and functional distance decay patterns across 149 datasets, finding taxonomic decay is stronger than functional decay, with mid-latitude datasets showing the fastest taxonomic spatial decay.

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

The paper identifies environmental predictors of electroactive bacterioplankton in small boreal lakes by analyzing EET genes and their correlation with DOM.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

This paper introduces a method using phase imaging and neural networks to classify cell cycle stages without fluorescence, achieving high accuracy in G1, S, and G2/M classification.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

The paper shows anionic lipids gate potassium conduction through Kir channels by interacting with the internal gate via fatty acyl tails.

This study identifies H2B.8 as a histone variant that mediates chromatin condensation in flowering plant sperm through phase separation, enabling nuclear compaction without transcriptional inhibition.

This study shows North American deer mice can be infected and transmit SARS-CoV-2, suggesting they may serve as a potential reservoir for the virus.

This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

This study identifies the SHREK family of proteins as broad-spectrum antiviral factors that inhibit HIV-1 and other viruses by blocking virus particle attachment to target cells.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study uses fMRI to show that amblyopia causes layer-specific changes in subcortical visual pathways, with reduced feedforward signals in the geniculostriate pathway and altered feedback signals in the retinotectal pathway.

This paper develops a hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening of neutralizing antibodies, viral variants, and antiviral drugs, showing increased infectivity of variants and enhanced neutralization by post-vaccination serum.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This paper introduces a method to assess cell viability without staining using phase imaging and deep learning, achieving 95% accuracy in distinguishing live and dead cells.

This study analyzes the genomic structure and adaptive potential of G. purpurascens, a landrace of G. hirsutum, to understand its biogeographic history and divergence from modern cultivars.

The paper identifies a Rubisco-binding motif that targets proteins to the pyrenoid and maintains its three sub-compartments.

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

This study shows retinoic acid reprograms enhancer landscapes in MYCN-amplified neuroblastoma cells, downregulating MYCN and inducing sympathetic differentiation.

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.