S. Liu

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

The paper identifies gene acquisitions in Xanthomonas vasicola pv. vasculorum genomes from the U.S. and Argentina, linking them to increased virulence through horizontal gene transfer, including a prophage from X. vasicola pv. holcicola.

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.

This study shows that overexpressing zebrafish miR-722 in HL-60 cells reduces chemotaxis and inflammation-related gene expression, suggesting miR-722 suppresses neutrophil migration.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

The paper identifies a supergene in rainbow trout that uses sex-dependent dominance to resolve sexual conflict, protecting polygenic variation without the drawbacks of sex chromosomes.

The paper compares nitrogen allocation in leaves of nitrogen-fixing and non-nitrogen-fixing tree species, finding lower photosynthetic nitrogen use efficiency in nitrogen-fixing species due to reduced allocation to Rubisco and bioenergetics.

CELPP evaluates docking workflows by challenging participants to predict new protein-ligand structures weekly, assessing accuracy to identify strengths and weaknesses in drug docking methods.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study shows high-glucose induces RPE apoptosis and inhibits mitophagy by disrupting the ROS/PINK1/Parkin pathway.

The paper evaluates virtual screening algorithms for two protein-protein interactions and finds random forest outperforms neural networks in prospective compound prioritization.

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

This paper identifies ShyB, a zinc-dependent endopeptidase in Vibrio cholerae, as a novel component of the Zur-mediated zinc starvation response that sustains cell growth under low-zinc conditions.

The paper identifies 63 nuclear protein-coding loci markers that are effective for avian phylogenetic and population genetic studies, showing comparable polymorphism to mitochondrial loci.

This study identifies a novel maize gene, glossy6, involved in epicuticular wax trafficking and drought tolerance by analyzing a mutant with reduced wax load and increased water loss.

The paper uses single-molecule fluorescence microscopy to study Cas10 dynamics in type III CRISPR-Cas systems, revealing conformational changes that distinguish self from nonself RNA.

The paper shows CMG helicase opens a single-stranded DNA gate to traverse forked junctions and resume replication after DNA damage, with Mcm10 facilitating this process.

This paper introduces DRRAFTER, a method to model RNA-protein complexes from cryoEM maps, showing it can build accurate RNA coordinates in real-world scenarios.

This study shows mixed-cropping of different rice cultivars increases grain yield and quality compared to mono-cropping systems.

This study shows that Pseudomonas aeruginosa surfing motility on mucin increases resistance to multiple antibiotics by dysregulating resistome genes.

The paper improves rice genome annotation by analyzing RNA-Seq and proteomics data, identifying 692 genomic loci with potential annotation updates.

The paper tests a theoretical framework predicting how to minimize energy dissipation in non-equilibrium processes by controlling the speed of a reaction coordinate based on a generalized friction coefficient.

ADS-J1 disassembles semen-derived amyloid fibrils and prevents their re-aggregation, showing potential as a microbicide and treatment for amyloid diseases.

This study shows that defective nuclear envelope assembly in micronuclei leads to chromothripsis by impairing nuclear import and genome integrity.

The paper identifies forest and prairie genomic domains based on CpG island density and shows their role in shaping cell-type-specific chromatin structures and genomic properties through phase separation mechanisms.

This paper develops HDL-AuNPs-BMS conjugates for leukemia treatment, showing enhanced drug delivery and epigenetic modulation in AML cells and mice.

This study characterizes two Toxoplasma PROPPINs homologous to ATG18/WIPI, revealing distinct specialized functions in autophagy-related processes.