S. Yamazaki

A novel kit mutant rat enables hematopoietic stem cell engraftment without irradiation

This study introduces a KitV834M mutant rat model that supports HSC engraftment without irradiation, offering a larger-scale alternative to mouse models for HSC research.

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

Apoplast-localized β-Glucosidase Elevates Isoflavone Accumulation in the Soybean Rhizosphere

This study shows that apoplast-localized β-glucosidase (ICHG) increases isoflavone accumulation in the soybean rhizosphere but is not required for plant-microbe interactions.

Neuronal E93 regulates metabolic homeostasis

This study shows neuronal E93 in Drosophila regulates adult metabolism and circadian rhythms by acting in GABA and MIP neurons, linking metamorphosis to metabolic homeostasis.

Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis

This paper develops a genetic toolkit for Arthrospira platensis and demonstrates acetaminophen production as a proof-of-concept for small molecule synthesis in an edible cyanobacterium.

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells

The paper presents a method to expand and profile genetically edited murine hematopoietic stem cells at clonal density to reduce genetic heterogeneity before transplantation.

A highly efficient reporter system for identifying and characterizing in vitro expanded hematopoietic stem cells

This paper introduces a reporter system to identify and characterize expanded hematopoietic stem cells, showing their molecular profile resembles fetal liver HSCs and shares gene expression signatures with functional HSCs from various sources.

THz irradiation inhibits cell division by affecting actin dynamics

This study shows THz irradiation inhibits cell division by preventing the disappearance of the contractile ring and promoting F-actin polymerization in human cells.

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

This study shows AMPK regulates cardiomyocyte shape by modulating microtubule turnover via CLIP-170 phosphorylation at intercalated discs.

Propagation of THz irradiation energy through aqueous layers: Demolition of actin filaments in living cells

THz radiation propagates through aqueous media and demolishes actin filaments in living cells without affecting cell viability.

Diurnal metabolic regulation of isoflavones and soyasaponins in soybean roots

This study investigates diurnal regulation of isoflavone and soyasaponin biosynthesis and secretion in soybean roots using transcriptome and metabolite analysis.

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression

This study identifies IL-11 as a marker for fibroblasts involved in colorectal cancer progression, showing their role in tumor development through a feed-forward loop.

Properties of rhizosphere soil associated with herbaceous plant roots analyzed using small-scale protocols

The study compares nutrient mineral content between bulk and rhizosphere soils of sorghum, finding higher nutrient concentrations in rhizosphere soil.