Sharon A Tooze

BCAS3 regulates WIPI2b via a direct interaction in the ATG16L1-binding cleft

The paper identifies BCAS3 as a novel interactor of WIPI2b that regulates its membrane association through interaction with PtdIns3P.

Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development

The paper identifies AIP as a regulator that links mTORC1 activation with catabolic metabolism during neonatal development, ensuring metabolic adaptation and survival.

ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair

The paper shows ATG9A and ARFIP2 work together to regulate PI4P levels for lysosomal repair during damage and bacterial infection.

Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution

This study uses in vitro reconstitution to investigate ATG8 protein localization and cargo recruitment on phagophore membranes, revealing their roles in membrane expansion and bending.

Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.

NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

Unraveling membrane properties at the organelle-level with LipidDyn

LipidDyn is a computational pipeline that analyzes MD simulations of membranes with varying compositions to extract properties like area per lipid and thickness.

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

This study shows that autophagy is essential for proper chondrocyte maturation and joint formation in zebrafish, with its disruption causing premature hypertrophy and developmental defects.

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

This study shows that WIPI2B expression counteracts age-related decline in autophagosome biogenesis in neurons, suggesting it as a therapeutic target for age-associated neurodegeneration.

AP-4 mediated ATG9A sorting underlies axonal and autophagosome biogenesis defects in a mouse model of AP-4 deficiency syndrome

This study shows that AP-4 deficiency in mice causes axonal and autophagosome biogenesis defects by impairing ATG9A sorting from the trans-Golgi network.