W. Feng

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

Endocytosis of very low-density lipoprotein particles: an unexpected mechanism for lipid acquisition by breast cancer cells

This study identifies receptor-mediated endocytosis of VLDL particles as a lipid acquisition mechanism in breast cancer cells, highlighting its importance alongside de novo lipogenesis.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

Gut segments outweigh the diet in shaping the intestinal microbiome composition in grass carp Ctenopharyngodon idellus

This study shows that gut segments, not diet, are the main factor shaping the intestinal microbiome in grass carp, with diet having a smaller impact in distal gut regions.

A microbially derived tyrosine sulfated peptide mimics a plant peptide hormone

The paper shows that a synthetic sulfated RaxX peptide mimics plant PSY peptides to promote root growth and that XA21 recognizes microbial RaxX to trigger immunity.

Stability and critical transitions in mutualistic ecological systems

This paper introduces a general model to predict instability and collapse in mutualistic ecological systems using basic ecological parameters and resolves open questions about interaction heterogeneity.