W. Li

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

This study identifies new epigenetic and genetic biomarkers for esophageal cancer using cfDNA and combines SALP-seq with machine learning.

The paper identifies a molecular pathway involving cxcr4a/cxcl12b and pdgfb that drives arterial-specific accumulation of vascular smooth muscle cells during zebrafish development.

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.

The paper identifies new RNA processing alterations and candidate target genes in glioblastoma cells after radiation exposure, suggesting potential strategies to improve treatment outcomes.

The paper shows that higher density cultures of hiPS-CMs increase Ik1 expression, leading to more stable electrophysiology and reduced spontaneous activity.

This study identifies RpvA, a LysR-type regulator in S. aureus, which controls persister formation and virulence by modulating metabolism and virulence gene expression.

This study identifies a new Asgard archaeal phylum, Gerdarchaeota, and shows their role in organic matter degradation in coastal sediments through genomic and transcriptomic analysis.

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

The paper presents a high-resolution structure of the Salmonella type III secretion export apparatus in situ, revealing membrane remodeling and a secretion pathway.

The paper investigates how AMF and PGPR affect microbial communities and PAH degradation in contaminated soils, finding that GVPS treatment enhances microbial diversity and plant growth but not PAH degradation.

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

The paper shows that long-term potentiation increases extrasynaptic exocytosis of GluN2A-containing NMDA receptors, primarily controlled by SNAP-23.

This study identifies metabolic changes in crayfish muscle and hepatopancreas due to CHH gene silencing, revealing impacts on amino acid, nucleotide, and energy metabolism beyond previous carbohydrate-focused findings.

The paper analyzes residue-residue interactions in rhodopsin using molecular dynamics and energy decomposition to identify key residues involved in retinal relaxation.

This study introduces SMdM to map nanoscale diffusivity variations in the cell and finds that local diffusivity is heterogeneous and influenced by subcellular structures and molecular charge.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

This study optimizes antimicrobial peptides to enhance their activity and specificity against E. coli by modifying structure and introducing a phage-displayed targeting moiety.

This paper analyzes 104 experimental Hb structures to show electrostatic repulsion drives Hb-S polymerization in sickle cell disease.

This study uses a microfluidic Tumor-Vasculature-on-a-Chip model and numerical simulations to investigate how tumor size and positioning affect drug concentration distribution in the tumor microenvironment.

This paper introduces a graphene-based method for delivering fluorescent probes into live cells and performing super-resolution microscopy with high efficiency and spatial control.

This paper introduces a new LC/MS-based RNA sequencing method that directly analyzes multiple-base modifications in RNA mixtures, enabling accurate sequencing and quantification of both canonical and noncanonical bases.

The paper shows hypotonic stress causes rapid, reversible vimentin cytoskeleton degradation via calcium release and calpain proteolysis, preceding changes in other cytoskeletal systems.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study develops a rapid LF-RPA assay for detecting Burkholderia pseudomallei with high specificity and sensitivity, suitable for point-of-care use.

The paper investigates S. aureus colonization and infection in Chinese NICU neonates, identifying common clones and risk factors for colonization.