W. Liu

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

This study develops a method to simultaneously measure voltage and mechanical waves in human iPSC-CMs using dye-free optical imaging, revealing new insights into electromechanical coupling and its sensitivity to pharmacological agents.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

The paper identifies EMT-related miRNAs as prognostic biomarkers in gastric cancer by analyzing TCGA data and validating their association with survival outcomes.

The paper maps mitonuclear epistasis in yeast by creating a novel recombinant population and identifies loci influencing mtDNA stability and mitotic growth.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

The paper identifies IsrR, an sRNA in Staphylococcus aureus, that regulates iron-containing enzyme mRNAs during iron starvation, enhancing bacterial survival in infection.

MCS-DETECT identifies a dual regulatory mechanism for riboMERCs, dependent on RRBP1 and modulated by Gp78 ubiquitin ligase activity.

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

This study identifies PTK7 as a positive allosteric modulator of GPR133 signaling in glioblastoma, showing that their interaction enhances receptor activation and is relevant to tumor pathogenesis.

This study generates and characterizes conditional mutants of yeast scaffolding proteins Boi1/2 and Bem1, revealing their essential functions in polarized growth and cell survival.

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

This study identifies nucleosome binding as a key activator of Sirt7 deacetylase activity, revealing its efficiency and limitations in chromatin context.

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This paper demonstrates a method to recycle PCR kits by depolymerizing DNA strands and regenerating nucleotides and primers for reuse.

This study identifies a unique chromatin state in invasive lobular breast cancer (ILC) driven by FOXA1-ER axis, leading to tamoxifen resistance and poor outcomes.

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

The paper demonstrates a method to recycle DNA into nucleotides and use them for PCR and qPCR, following a circular economy approach.

This study identifies 6S RNA's role in enhancing rifampicin resistance in Staphylococcus aureus and shows similar effects in other pathogens.

This study identifies PIMT as a suppressor of endothelial activation and vascular inflammation by methylating TRAF6, inhibiting its function and reducing ICAM-1 expression.