W. Ma

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

This paper introduces a method to image endogenous mRNAs in live animals with high temporal resolution and applies it to study gene expression dynamics in C. elegans epidermis.

This study uses X-ray diffraction to compare thick filament activation dynamics in fast and slow-twitch rat muscles, finding distinct structural transitions that may explain their differing contraction properties.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

This study identifies 13 type III effectors in Pseudomonas syringae with potential NADase activity, showing that NAD+ manipulation is a key virulence strategy in plant pathogens.

The paper identifies a pandemic clonal lineage of the wheat blast fungus that originated in South America and spread to Asia and Africa, showing it can be controlled by Rmg8 but may develop fungicide resistance and recombine with African lineages.

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

This study shows that cardiac myosin filaments are directly regulated by calcium, transitioning from inactive to active states through structural changes.

This study examines reassortment dynamics of influenza A virus in guinea pigs, ferrets, and swine, finding reassortment is common but more frequent in ferrets and guinea pigs than swine, with spatial compartmentalization observed.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

This study investigates how different polyubiquitin chain lengths and linkages affect UBQLN2's liquid-liquid phase separation, showing that extended chains enhance while compact chains inhibit it.

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This paper introduces a method to quantify myofibrillar orientation in cardiac muscle and shows it detects greater disorientation in diseased tissue compared to healthy controls.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

This study profiles the transcriptome of Candidatus Liberibacter asiaticus in citrus and psyllids, identifying gene expression patterns and differentially expressed genes between hosts.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

The paper identifies effectors from plant pathogens that specifically target subsets of NRC immune receptor proteins, revealing convergent strategies to counteract redundant nodes in the NLR network.

This study shows that SARS-CoV-2 can re-infect previously infected cats, but viral shedding is insufficient for transmission to naive cats.

This study investigates the DNA unwinding mechanism of UvrD, a non-hexameric helicase, revealing a stepwise translocation with variable base pair steps and strand sequestration.

This study compares how two myosin inhibitors, mavacamten and blebbistatin, stabilize myosin in distinct structural and functional states, potentially affecting cardiac function differently.

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

This study develops and tests bat influenza-based live attenuated vaccines for pigs, showing they reduce viral replication and lesions without causing vaccine-associated enhanced respiratory disease.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

Introgression of the 1Ay21* HMW-GS increases wheat grain protein content and improves bread-making quality by reshaping the grain proteome network.

The paper shows enhancers regulate 3'UTR isoform expression by controlling 3' end processing activity in multi-UTR genes.

This study assesses SARS-CoV-2 susceptibility in swine cells and pigs, finding replication in cell lines but no infection or transmission in pigs.

This study investigates SARS-CoV-2 infection, disease progression, and transmission in domestic cats through experimental challenge and monitoring.