X. Huang

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

This study identifies CATSPER{theta} as essential for CatSper channel assembly in sperm flagella, revealing its role in channel formation and flagellar trafficking, leading to male infertility in its absence.

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study develops a co-editing strategy to generate transgene-free, gene-edited plants in the T0 generation using Agrobacterium-mediated transient expression of CBE/gRNA and Cas12a/crRNA-GFP.

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study shows that Wg signaling reduces lipid accumulation in Drosophila adipocytes by repressing lipogenesis and fatty acid β-oxidation while promoting lipolysis.

This study compares ACE2-derived and engineered Spike-binding peptide entry inhibitors against SARS-CoV-2 variants, finding that an optimized ACE2 derivative neutralizes all tested variants, while peptides show variable efficacy with resistance observed in Beta, Gamma, and Omicron variants.

The paper identifies archaic admixture in eastern gorillas using whole genome sequences and ABC with neural networks, finding introgression from a ghost lineage into their common ancestor.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

This study identifies LOXL2 and its variant L2{Delta}13 as deacetylases that reprogram tumor metabolism by deacetylating aldolase A, promoting tumor progression.

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

This paper introduces a memory-enriched model using TCL-GME to efficiently capture long-time biochemical dynamics from short simulations, reducing data requirements and improving accuracy.

This paper introduces a hybrid method combining a physical model with deep learning to improve structured illumination microscopy, achieving better artifact suppression and resolution in low SNR images.

The paper modifies Gq and G11 biosensors to enhance sensitivity for detecting Gq/11 activation in GPCRs, including those with cancer-associated mutations.

MaCroDNA integrates single-cell DNA and RNA data to better understand tumor heterogeneity, showing improved accuracy and speed over existing methods.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study investigates multidimensional plasticity in Ciona savignyi under salinity stress, showing gene expression, alternative splicing, and polyadenylation each play distinct roles in adaptation.

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.