X. Wang

This study identifies a four-component dehydrogenase gene cluster responsible for 3-hydroxypyridine degradation in Ensifer adhaerens HP1.

This study identifies stem cell-like GBM cells outside the contrast-enhancing region and proliferative lymphocytes in GBM patients' blood, linking them to recurrence and immunotherapy.

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

The paper identifies a novel glymphatic pathway in the optic nerve for clearing amyloid-beta from the vitreous, which is impaired in glaucoma.

The paper identifies two distinct mechanisms controlling bimodal flagellar gene expression in Salmonella enterica, one involving a feedback loop and the other a developmental checkpoint.

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

This study identifies Plasmodium α-tubulin-1 as a binding partner of Anopheles FREP1, showing that anti-α-tubulin antibodies inhibit malaria transmission to mosquitoes.

This study identifies a link between geometric features of melanoma aggregates and reprogramming to stem cell-like initiating cells through histone modifications.

This study identifies viral genetic integrations in gut microbes associated with microbial dysbiosis in colorectal carcinoma tumorigenesis.

This study identifies a new Asgard archaeal phylum, Gerdarchaeota, and shows their role in organic matter degradation in coastal sediments through genomic and transcriptomic analysis.

This study shows that inhibiting retinoic acid signaling early in differentiation rapidly generates ventricular-like cardiomyocytes from human iPSCs with higher MLC2V expression.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study shows that daratumumab targets CD38+ NK cells to induce immune activation and anti-myeloma activity despite reducing total NK cell frequency.

This study maps basophil and mast cell differentiation using single-cell RNA sequencing and flow cytometry in mice, revealing distinct trajectories and lineage-specific gene regulation.

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper uses 19F-NMR and Cryo-EM to study conformational dynamics of a glutamate transporter homolog, identifying three states and measuring conformational exchange rates.

This study uses nanopore sensing to analyze actin dynamics and drug binding in native, unmodified actin molecules, revealing transitional states and binding stoichiometries.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

This study investigates how Chlamydomonas sp. UWO241 maintains high cyclic electron flow and rewired metabolism under high salinity stress.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

This study investigates genetic diversity in Norway spruce, finding low diversity despite large population size, attributed to bottlenecks, natural selection, and low mutation rates.

This study identifies OMCP as a cowpox virus protein that directly binds NKG2D to evade immune detection, revealing structural insights into its high-affinity interaction and zoonotic potential.

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This study identifies PsaE's role in regulating psaA in Yersinia pestis, showing its temperature- and pH-dependent expression and binding sites across the genome.

This paper introduces a system for conditionally knocking out genes in plants using CRISPR-Cas9 and the estrogen-inducible XVE system.

The paper models how changes in heart rate affect ocular pulse and biomechanical properties of the optic nerve head, finding decreased pulse amplitude and increased stiffness with higher heart rates.

This study shows that overexpression of MAN1B1 in prostate cancer cells reduces migration and promotes EMT phenotype.