X. Wang

The paper identifies candidate foundation species in Chinese forests across a latitudinal gradient and finds they are more common in temperate zones than in tropical or boreal regions.

This study develops an estrogen-inducible CRISPR/Cas9 system in Nicotiana tabacum and demonstrates its efficacy in inducing targeted mutagenesis of the NtPDS gene.

This study develops BCMA/CS1 bispecific CAR-T cells that effectively target heterogeneous multiple myeloma, showing improved activity and durable tumor-free survival compared to single-target CAR-T cells.

This paper shows that deleting Pten and Dicer1 in mice leads to poorly-differentiated endometrial adenocarcinoma with molecular features similar to human DICER1-mutant cancers.

This paper introduces MorphEUS, a morphological profiling method that classifies drugs based on their effects on Mycobacterium tuberculosis morphology, identifying both primary and off-target pathways of action.

This study uses CRISPRi to systematically analyze coding and non-coding elements in E. coli, revealing conditional essentiality and novel insights into promoter and TFBS targeting.

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

The paper reports cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins, revealing structural similarities and evolutionary insights into coronavirus evolution.

This study reveals hidden research bias in urothelial carcinoma cell lines due to driver gene loss from random mutation, suggesting next-generation sequencing is needed and conditionally reprogrammed cells may be a better alternative.

This study shows that Mitofusin 2 suppresses Rac activation to regulate neutrophil adhesive migration and actin cytoskeleton dynamics.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

This study presents a chromosome-scale genome assembly of teff and reveals exceptional subgenome stability and functional divergence, which may contribute to its resilience and diversification.

ATHENA is an open-source software that automates wireframe DNA origami design using 2D/3D geometries and 2HB/6HB edges, enabling sequence generation and integration with simulation tools.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This study finds that KALRN mutations enhance anti-tumor immunity and immunotherapy response in cancer by increasing tumor mutation burden and PD-L1 expression.

The paper introduces DASC, a method to distinguish abortive clathrin coats from clathrin-coated pits in live-cell imaging, enabling sensitive analysis of CME progression in EAP knockdown conditions.

The paper predicts nelfinavir as a potential inhibitor of 2019-nCov main protease using homology modeling, molecular docking, and binding free energy calculations.

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

This paper introduces Random Illumination Microscopy (RIM), a super-resolution technique that achieves high-resolution, low-toxicity, and fast imaging for live-cell studies.

The paper develops a tandem tension sensor to measure integrin molecular tensions in live cells and finds that these tensions decrease with increasing substrate rigidity.

The paper treats onion epidermal walls with pectin methylesterase, showing it softens the wall but reduces acid-induced creep.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

This paper shows estrogen reduces growth of HPV-positive epithelial cells through two mechanisms, suggesting it could be a therapeutic for HPV+HNSCC.