X. Wang

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

This study shows IL-10 promotes wound healing by recruiting endothelial progenitor cells through STAT3-dependent regulation of VEGF and SDF-1 in both control and diabetic wounds.

This study shows that the in vitro and in vivo cellular uptake and trafficking of miktoarm copolymer nanomicelles (MCNs) correlate, with FRET efficiency changes reflecting transport mechanisms and probe uptake behavior.

This study shows that DMSO-differentiated HL-60 cells exhibit chemotaxis and swarming toward zymosan particles but with less organized movement and smaller swarms compared to primary neutrophils.

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

The paper examines the roles of three wheat glutamine synthetase isozymes in nitrogen assimilation and translocation, showing distinct functions and synergistic effects.

The paper engineers a polymerase to monitor electrical activity by adding biotinylatable contacts, showing enhanced current fluctuations when activated.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

The paper compares optic nerve tortuosity and globe proptosis between glaucoma and normal subjects using MRI, finding greater tortuosity in normal eyes during adduction and higher proptosis in glaucoma subjects in primary gaze.

The paper tests if post-MI human MNCs from clinical trials show impaired therapeutic efficacy compared to healthy donor MNCs in mouse models, finding no therapeutic benefit in either TIME or LateTIME patient MNCs.

The paper defines reference ranges for spot urine copper excretion in preschool children and identifies optimal cutoff values for pre-symptomatic Wilson’s disease screening.

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

CASLFA enables rapid, specific detection of pathogens and GMOs with high sensitivity and no technical expertise.

This paper evaluates LiDAR metrics for predicting forest understory cover using mixed-effects and Random Forest models, finding high predictive accuracy with voxel-based metrics.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

The paper examines how TP53 mutations affect antitumor immunity differently across cancer types, finding varying correlations with immune signatures and tumor mutation burden.

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

The paper investigates the mechanisms controlling E2F8 dynamics during the cell cycle using cell-free systems, revealing phosphorylation, ubiquitination, and transcriptional regulation.

This paper identifies the role of TYLCV V2 protein in facilitating the nuclear export of V1 protein and viral systemic infection through host exportin and V1-V2 interaction.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

The paper develops a method to estimate immune cell content in tumors using scRNA-seq reference data, showing improved performance over existing methods in distinguishing immune subtypes.

This study shows glycogen metabolism via the oxidative pentose phosphate pathway (OPPP) initiates photosynthesis in cyanobacteria by modulating NADPH levels during dark-light transitions.

The paper shows how regional climate differences affect salmon lice population dynamics, stage structure, and management strategies.

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.