X. Wang

The paper reports a quadruple mutant of hepatitis B virus showing moderate resistance to tenofovir and demonstrates that combination therapy with entecavir and tenofovir effectively suppresses this resistant mutant.

This study develops PSMA-targeted nanobubbles for real-time ultrasound imaging of prostate cancer in mice, showing improved tumor detection and retention.

This study shows the photoactive site in GtACR1 affects chloride conductance and channel closing through electrostatic changes and distance-dependent effects.

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.

The paper develops improved CRISPR/Cas9 methods for genome editing in Culex quinquefasciatus, achieving higher embryo survival and germline mutagenesis rates.

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

This study investigates the antifungal activity of ε-poly-L-lysine against Candida albicans planktonic cells and biofilms, finding it inhibits growth, disrupts morphogenesis, and induces oxidative stress.

This study identifies IL17 and senescence as regulators of the foreign body response, showing their roles in fibrosis and potential as therapeutic targets.

This study quantitatively investigates how RNA polymerases interact with condensin loop extrusion, showing RNAPs act as steric barriers that impede the process, particularly in highly transcribed regions.

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

This paper develops a laser-based system to record subcellular neuron activities with high sensitivity, showing that ultrasound can modulate neuron laser emissions.

This study identifies G3BP1 as a host factor essential for norovirus infection and reveals its role in VPg-dependent translation initiation.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This study uses transposon-insertion sequencing to identify genes required for EHEC growth in vitro and in vivo, revealing new factors critical for intestinal colonization.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

PDE1 inhibition enhances proteasomal degradation of misfolded proteins via PKA and PKG activation, reducing cardiac proteinopathy and HFpEF in CryABR120G mice.

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

This study shows that fast-cycling granulocyte-macrophage progenitors are more likely to transform into leukemia when expressing the MLL-AF9 oncogene.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

This paper shows that SIRT1 deacetylates WRN to regulate its interaction with E1-E2 replicating DNA, controlling replication fidelity and quantity in HPV16.

The paper evaluates pKa prediction methods using a dataset of kinase inhibitor-like fragments measured by UV absorbance and NMR.

This paper identifies and characterizes a novel paraoxonase-like enzyme in Trichoderma atroviride strain T23 that degrades DDVP and related organophosphate-oxons, showing high activity and specific kinetic parameters.

This study shows that FADD is critical for intestinal intraepithelial lymphocyte (IEL) development, particularly affecting CD8αα+ TCRγδ+ T cells, and its loss worsens colitis.

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

This study demonstrates that FAdV-4 penton-dodecahedron (Pt-Dd) and recombinant fiber-1 proteins induce strong immune responses and 100% protection against FAdV-4 in chickens, making them viable vaccine candidates.