X. Zhang

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.

The paper analyzes microbial nitrogen acquisition strategies across diverse genomes to identify ecological and physiological controls on their distribution.

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

This study identifies fucosylated glycoproteins and glycolipids as opposing factors in cholera toxin binding and intoxication in intestinal cells.

The paper shows TIR domains interact with EDS1 family proteins and helper NLRs to propagate immune signaling in plants.

This study shows that multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus, forming high molecular weight RNPs, but pure GU-repeats impair TDP-43 function.

This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

The paper identifies H2O2-mediated sulfenylation of CHE as a mechanism for systemic acquired resistance in plants.

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

This study identifies the complete pathway for progesterone biosynthesis in Marsdenia tenacissima, involving specific P450scc and MtHSD5 enzymes, enabling sustainable steroid hormone drug synthesis.

This study develops potent dual BET/HDAC inhibitors through pharmacophore merging and structure-guided optimization, showing improved potency and efficacy in cancer cell models.

The paper defines the structural hierarchy of An. gambiae cSPs in the melanization cascade and shows their functional interactions with cSPHs.

This study shows radial glia use integrin aVb8-TGFb1 signaling to promote microglial development, with disruptions causing dysmature microglia and neuromotor symptoms.

The paper uses cryo-EM to analyze ribosome conformations in yeast, revealing dynamics of the eukaryotic elongation cycle with elongation factors.

This study shows MYCN drives oncogenesis by cooperating with WDR5 to activate MYC targets and G9a to repress differentiation genes, and targeting both synergistically inhibits neuroblastoma growth.

The paper reports the natural circulation of SFTSV between Asian long-horned ticks and hedgehogs in Beijing, highlighting their role in maintaining the virus in the urban ecosystem.

The paper presents a method to quantitatively control surface density and purity of anchor-bearing molecules by adjusting incubation concentrations and demonstrates its application with biotin anchors.

This study shows that tumor-derived exosomal miR-222-3p activates fibroblasts to promote renal cancer progression by inducing metabolic changes and cytokine secretion.

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.

This study uses in silico models to show that modulating the SK current in human atrial myocytes can both promote and prevent arrhythmias depending on the underlying mechanism.

The paper determines the structure of VP39, a baculovirus capsid protein, revealing its assembly into a helical tube and conserved fold across species.

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

This study identifies MYCBP2 as a critical ubiquitin ligase that stabilizes EPHB2 and facilitates its signaling function through interactions with FBXO45 and ephrin-B ligands.

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

This study presents cryo-EM structures of σ54 with increasing RNA length, revealing the mechanism of σ54 displacement and promoter escape during bacterial transcription initiation.

This study shows METTL16 suppresses KSHV lytic replication by regulating the SAM cycle and redox homeostasis.

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

This study investigates how carotenoid assembly affects quinone diffusion and the structure of the reaction center-light harvesting complex in Roseiflexus castenholzii.