X. Zhang

This study engineers muscle cells to eliminate the need for costly FGF2 in cultured meat production by enabling autocrine signaling.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

The paper describes a new Cambrian sponge fossil with a long stalk, indicating an early adaptation to low-oxygen environments and a deep origin of stalk-bearing morphology in hexactinellid sponges.

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

This study shows that phosphorylation of Sfr1 in the Swi5-Sfr1 complex regulates its interaction with Rad51, affecting DNA repair efficiency in yeast.

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

This study investigates the structural and functional roles of Zn2+/H+ antiport in YiiP using cryo-EM, thermophoresis, and simulations, revealing a transport stoichiometry of 1 Zn2+ to 2-3 H+.

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

This study identifies miR-193a-5p as a regulator of vascular smooth muscle cell proliferation and migration in aortic aneurysms, showing that RelB represses its expression.

The paper identifies novel transmembrane proteins enriched at the nuclear envelope using proteomics and validates their localization and function.

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

This study shows that aged bone marrow-derived cells increase smooth muscle cell polyclonality in atherosclerotic plaques through reduced TET2 and increased TNF signaling.

This paper identifies and characterizes the gene PLATZ-A1 underlying the GA-sensitive dwarfing locus RHT25 in wheat, showing it interacts with RHT1 and can modulate plant height.

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

This paper shows that phosphorylation enhances Mec1-Ddc2 recruitment to RPA-ssDNA, facilitating DNA damage checkpoint signaling in yeast.

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

This paper conducts a bibliometric analysis of cancer alternative splicing research from 2012 to 2021, identifying trends, key institutions, and research areas.

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

This paper develops genetically immortalized bovine satellite cells for cultured meat production, achieving over 120 doublings while maintaining myogenic differentiation capacity.

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.