X. Zhao

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

This study compares gut microbiota differences between obese children and adults, finding greater alteration in children and highlighting the need for early intervention.

The paper studies the evolution of two gene networks in Solanum chilense under drought stress, finding that the metabolic network is younger and under recent selection, while the cell-cycle network is ancient and conserved.

This study reveals that AcrIIC5 mimics dsDNA to inhibit type II-C Cas9 by blocking PAM recognition, providing insights into its mechanism and evolutionary convergence.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

The paper introduces GENERALIST, a generative model for protein sequence families that accurately captures amino acid covariation and predicts stable sequences.

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

This study shows light-activated molecular machines can remotely stimulate intercellular calcium waves, controlling muscle contraction in vitro and animal behavior in vivo.

The paper identifies nsp3-4 as the minimal components forming a DMV-spanning pore in SARS-CoV-2 replication organelles, critical for membrane curvature and DMV formation.

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

KaryoCreate generates chromosome-specific aneuploidy by targeting centromeres with CRISPR, showing it can induce gains or losses of targeted chromosomes in human cells.

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

This study sequenced the genome of water wisteria, revealing genes and pathways involved in its environmental adaptation and leaf shape changes.

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

The paper maps AP complex interactions in Arabidopsis, identifying P34 as a stability regulator of clathrin-mediated endocytosis and post-Golgi trafficking.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

This study shows that Nlrc4 inflammasome recognition of Salmonella flagellin is critical for mucosal immunity but not systemic infection.

This study analyzes the temporal transcriptome changes in porcine macrophages infected with different ASFV strains to understand viral pathogenicity and host response dynamics.

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.