X. Zhao

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

The paper investigates how marine bacteria respond to opposing chemotactic signals from crude oil components using a mathematical model.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

This study uses a multiscale model to predict E. coli migration in response to competing chemoeffectors, showing direction is controlled by relative concentrations.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

The paper identifies small-molecule agonists for the orphan receptor GPRC5A using chemoproteomics of microbiota metabolites, revealing bacterial sources and key residues involved in ligand binding.

This study uses proteogenomic analysis to show that gene expression regulation differs across cellular pathways and tissues, with protein-level regulation dominating in some pathways and RNA-level regulation in others.

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

This study examines beetle evolution through the end-Permian mass extinction, showing xylophagous beetles declined due to forest collapse and later rebounded with forest recovery.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

This study identifies B1-type cyclins' role in microtubule organization during Arabidopsis cell division, showing their importance in mitotic networks and interactions with GIP1.

The paper introduces ultraID, a compact and efficient biotin ligase for proximity-dependent biotinylation, demonstrating its use in probing interactomes with high temporal resolution.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

This paper introduces BATTLES, a high-throughput method that applies biomechanical force to screen pMHCs for T-cell activation, revealing force- and sequence-dependent responses.

This study identifies and characterizes brevibacillin 2V, a novel antimicrobial lipopeptide with low hemolytic activity against eukaryotic cells, showing promise for antibiotic development.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

This study examines how acute isolation affects vocal and non-vocal social behaviors in male and female mice during same-sex and opposite-sex interactions, finding stronger effects in females.

An off-the-shelf bioadhesive patch is introduced for facile sutureless repair of gastrointestinal defects, addressing various limitations of conventional suture-based treatments.