Y. Huang

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

This study examines how adaptive evolution in cold-adapted Drosophila populations affects gene regulatory plasticity and canalization, finding that adaptive changes neutralize ancestral plasticity and may reduce genetic canalization for gene expression but not splicing.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

The paper identifies BMP1 isoforms with opposite abundance patterns in NSCLC and control plasma proteomes, suggesting differential regulation linked to disease progression.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

The paper identifies core bacterial taxa and mobile genetic elements associated with extracellular antibiotic resistance genes in water compartments.

The paper examines wall ingrowth deposition in Arabidopsis phloem parenchyma transfer cells, showing it occurs adjacent to sieve elements rather than companion cells and is more abundant in abaxial positions.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study identifies two snoRNA-derived fragments, sdRNA-D19b and sdRNA-A24, that promote castration-resistant prostate cancer by downregulating tumor suppressors and conferring drug resistance.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

The paper improves Spike protein expression in CHO cells by developing truncations that outperform full-length Spike and RBD in expression levels and antibody binding.

This study evaluates management strategies for conserving climate-threatened species using a stochastic metacommunity model, finding corridors and assisted migration most effective in reducing extinction.

This study investigates how trans-4-hydroxyproline affects the metabolism of C. difficile and commensal Clostridia, revealing differential gene expression and microbiota changes in mice.

This study identifies tRNA fragments (tRFs) in Salmonella OMVs that inhibit bacteriophage P22 infection, showing their role in antiviral defense.

This study examines how tendon viscoelasticity affects force distribution across sutures in tendon-to-bone repairs and shows that optimized suture stiffness and spacing can balance forces effectively.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

The paper examines sex ratio polymorphism across 23 Caenorhabditis nematode species, finding that 12 species show strain-level variation, and challenges the sperm competition model as the sole explanation for biased sex ratios.

This study compares disease outcomes in domestic pigs infected with Mycobacterium bovis and Mycobacterium tuberculosis, showing differences in pathology and virulence.

This study identifies a transcriptional network involving SCL28 and AtSMOS1 that regulates cell size and number in Arabidopsis by controlling G2 phase transitions through CDK inhibitors.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This study uses single-cell sequencing to analyze immune responses in acute Kawasaki disease before and after treatment, identifying key gene expression changes and immune cell dynamics.

This study evaluates the anti-SARS-CoV-2 activity of Artemisia annua hot-water extracts against multiple variants, finding potent efficacy with low toxicity.

This study compares two methods for isolating plant extracellular vesicles and recommends a detailed protocol for Arabidopsis thaliana, including differential ultracentrifugation and immunoaffinity capture for purification.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

The paper shows that annual life history in killifishes is linked to higher evolutionary rates in genes involved in development and metabolism.

This paper introduces a method to monitor phloem and xylem reconnections in grafted watermelon seedlings using specific fluorescent tracers and finds that vascular reconnections are not timely separated in self-grafted watermelon.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.