Y. Liu

This study examines wall-following behavior in Sinocyclocheilus cavefish, finding that eyeless species exhibit enhanced behavior compared to sighted ones, with phylogenetic patterns linking behavior intensity to subterranean adaptation.

The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.

This study identifies Schisandrin B's mechanism of action in colon cancer, showing it induces cell cycle arrest and apoptosis via the CHOP signalling pathway.

The paper identifies 56 metagenome-assembled genomes of Bathyarchaeia viruses and describes their CRISPR system components, revealing potential counter-defense mechanisms.

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

This study shows Epstein-Barr virus BRRF1 induces BTN2A1 in nasopharyngeal carcinoma cells through the IL-22/JAK3-STAT3 pathway, enhancing Vγ9Vδ2 T cell anti-tumor activity.

This study identifies genes involved in global and local adaptation to aridity in Gymnocarpos przewalskii, finding limited overlap between the two processes.

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

This study identifies a metabolite interaction between barley and the fungal pathogen Bipolaris sorokiniana, revealing that plant-produced hordedanes both inhibit other fungi and promote pathogen growth.

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

The paper identifies a novel UEV-Vps23 family protein in Asgard archaea that mediates an ancient ESCRT-ubiquitin interplay, suggesting this pathway predates eukaryotic endomembrane systems.

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

This study identifies a specific subset of tumor-associated endothelial cells in PDAC and develops a prognostic model, TaEMS, to predict patient outcomes based on immune and cellular pathway profiles.

The paper designs modular ligands with phase-separation modalities to induce apoptosis in tumor cells through interreceptor clustering and conditional activation.

This study examines the fitness tradeoffs of multidrug efflux pumps in E. coli under acidic or basic conditions and in the presence of aromatic phytochemicals, showing that lipophilic non-acidic molecules select against AcrAB-TolC without benefiting other pumps.

This study identifies habitat-related transcriptional differences in skin traits of Sinocyclocheilus cavefish using comparative transcriptomics and RNA-seq.

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

This study examines how diabetes and hypertension affect vasomotion spectral characteristics at specific acupoints using Laser Doppler Flowmetry and signal analysis techniques.

This paper develops novel glycan probes with a tri-functional linker for generating noncovalent and covalent arrays, revealing differences in glycan binding by various proteins on different array platforms.

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

The paper identifies a limitation in mutual information-based demixing for ultra-multiplexed fluorescence imaging and proposes a method to improve accuracy by selecting regions with low spatial similarity.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

This study identifies ribosome biogenesis as a key driver of EMT/MET transitions in breast cancer and shows that targeting this pathway enhances chemotherapy efficacy against chemoresistant tumors.

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.