Y. Liu

This study examines how acute stress affects working memory in pilots under varying memory loads, finding an interaction where stress may improve accuracy in moderate loads.

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

The paper identifies FBXW11 as a ubiquitin ligase that targets IL-17RA for proteasomal degradation through lysine 27-linked polyubiquitin chains.

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

The paper reflects on the experiences of UK infectious disease modellers during the COVID-19 pandemic, identifying challenges and proposing recommendations for future epidemic responses.

The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

This paper determines the structure of crescentin filaments using cryo-EM, revealing an octameric, non-polar filament with unique contacts compared to eukaryotic intermediate filaments.

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

The paper identifies the BcTir/Tpr system in Bacillus cereus as a defense mechanism against phage infection, showing BcTpr's dual role in NAD+ depletion and cADPR isomer production.

The paper identifies a Ctsk+Fmod+ periosteal cell subset in jaw bones that is impaired by Spp1 secreted by macrophages, highlighting a potential target for improving bone grafting.

The paper develops a theoretical framework explaining particle behavior at the air-water interface in cryoEM and validates it experimentally using surfactants to improve structural determination.

The paper identifies a C-terminal tripeptide that directs Fe-S cluster insertion into cytosolic and nuclear proteins by binding to the CIA-targeting complex.

This study develops a theranostic gold nanoparticle for detecting and treating biofilm infections using photothermal ablation and photoacoustic imaging, showing superior efficacy against oral and wound infections compared to chlorhexidine.

This study shows sulfur oxidation and reduction are coupled to nitrogen fixation in the roots of Spartina alterniflora, with a novel symbiosis involving Candidatus Thiodiazotropha.

The paper investigates how spatial confinement in MAP scaffolds affects immune cell recruitment and wound healing, finding that larger pores promote a balanced macrophage response and better regeneration.

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

The paper reinterprets the mechanism of fast inactivation in voltage-gated Na+ channels using ionic and gating current data, identifying two hydrophobic rings at the bottom of S6 as the inactivation gate.

This study identifies that the cargo protein P49 is loaded onto extracellular membrane vesicles of Shewanella vesiculosa HM13 via interaction with capsular polysaccharide (CPS).

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

This study identifies a mechanism by which gut tumors in Drosophila induce kidney dysfunction through Pvf1-mediated signaling.

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

The paper uses imaging methods to study how nuclear bodies protect TDP-43 from degradation during stress by monitoring its folding states in live cells.

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

This paper identifies the Forssman glycolipid as a receptor for sheep polyomavirus and reports the first viral protein specifically binding to this antigen.

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

The paper examines altered receptor specificities of H3N2 influenza viruses using NMR and computational methods to identify binding interactions with extended N-glycans.

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.