Y. Tian

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

This paper engineers sorghum to overproduce 4-hydroxybenzoic acid by expressing modified bacterial enzymes, resulting in 1.56-1.72% dry weight accumulation without affecting biomass or agronomic traits.

The paper investigates the structural basis of latency in TGF-beta family members by comparing conformational states and hydrogen-deuterium exchange patterns across multiple family members.

This study examines how temperature affects the behavior and molecular responses of Neptunea cumingii, showing significant physiological and transcriptomic changes outside the optimal temperature range of 8–16°C.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study uses RNA-Seq to analyze FV3-infected Xenopus tissues, identifying viral gene expression patterns and molecular mimics of host IFN signaling components.

This study demonstrates that GdDO3NI, a T1 MRI contrast agent, effectively images hypoxia in the injured brain after TBI, validated by immunohistochemistry.

This study shows that using the same calibration materials and points improves interlaboratory and inter-platform comparison of fluorescent submicron particles.

This study investigates how β1/β4 subunits and the RKK segment of Slo1 regulate BK channel gate opening through electrostatic interactions.

This study compares the performance of Autof MS 1000 and Bruker MALDI-TOF MS systems in identifying Nocardia species using clinical isolates and sequence analysis as a reference.

This paper uses cryo-electron tomography to visualize how different Aβ assembly forms interact with lipid membranes, revealing that oligomers and protofibrils disrupt membrane integrity while monomers and fibrils have minimal impact.

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

This study shows that BCP and Pre-C mutations in HBV increase viral replication but reduce immune tolerance, with Pre-C mutations causing more severe immune responses and shorter viral persistence in mice.

The paper identifies ACE2 and IL-6 as non-canonical interferon-stimulated genes with epigenetic features linked to COVID-19 susceptibility across vertebrates.

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study investigates the micro- and macroevolution of Prevotella copri-containing lineage in primate guts, revealing co-evolution with humans, host jumping, and horizontal gene transfer.

This study optimizes metagenomic sequencing for diagnosing central nervous system infections by establishing detection thresholds and reducing false positives through computational filters and controls.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This study investigates the conformational states of full-length Bcl-xL in soluble and membrane-anchored forms using NMR, MD simulations, and ITC to understand its structure and ligand binding.

The paper introduces DPSN, a database that standardizes short names of amplicon-sequencing primers to reduce ambiguity and improve communication.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

This paper identifies and characterizes 359 RXLR effectors in nine Pythium species, revealing evolutionary patterns and functional roles in host interactions.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.