Y. Yang

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

The paper analyzes bacterial diversity succession in compost made from pig manure and wood chips using 16S rRNA gene analysis, showing shifts in microbial phyla over composting stages.

This study investigates how AMPK activity and energy metabolism change in yak muscle during postmortem aging using AICAR and STO-609.

This study identifies sr8384, a novel small noncoding RNA in Clostridium acetobutylicum, which regulates growth and solvent synthesis, and shows its functional conservation in another clostridial species.

The paper analyzes the miRNA-mRNA network regulated by LMP1 in NPC using microarray data to identify differentially expressed miRNAs and genes and construct interaction models.

This study analyzes the pan-genome of Staphylococcus epidermidis to identify genomic factors associated with its adaptation to diverse niches and pathogenicity.

This study shows that inhibiting TG2 increases radiosensitivity in NSCLC by disrupting TOPOIIα-mediated DNA repair.

This study identifies a plasma circular RNA panel with higher diagnostic accuracy than AFP for detecting HBV-related hepatocellular carcinoma.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

This meta-analysis evaluates immunosuppressive treatment in IgA nephropathy, finding reduced proteinuria and ESRD risk but increased adverse effects.

This paper introduces a time-resolved digital immunoassay using plasmonic imaging to rapidly and sensitively quantify procalcitonin with a low limit of detection and wide dynamic range.

The paper proposes a deep learning approach for clutter suppression in ultrasound imaging, showing improved image quality and contrast compared to existing methods.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study shows high-glucose induces RPE apoptosis and inhibits mitophagy by disrupting the ROS/PINK1/Parkin pathway.

This study identifies an optimal T-DNA architecture for Cas9-mediated mutagenesis in Arabidopsis, resulting in stable mutations in the first generation.

This paper demonstrates that the Staphylococcal protein Sbi can be used as a vaccine adjuvant by promoting natural opsonisation of antigens with C3 fragments, enhancing immune responses.

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.

This study shows that E. coli lifespan follows the Gompertz law of mortality, with ageing rate modulated by maintenance investment in response to environmental constraints.

This study shows that enforced PIPKH expression changes PtdIns(4,5)P2 distribution and affects the localization of small G-proteins like K-Ras and Rac1.

This study identifies NudCL2 as a cochaperone that stabilizes cohesin subunits by modulating Hsp90 ATPase activity, preventing mitotic defects and sister chromatid separation.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

This study shows that TXNIP mediates ER stress-induced NLRP3 inflammasome activation, leading to IL-1β production in preeclampsia.

This paper identifies BceR as a key regulator in Group B Streptococcus virulence, antimicrobial resistance, and stress response through functional analysis of a non-invasive strain.

This study identifies BmrR as a MarR family regulator that autoregulates the bmrRAB operon in B. longum BBMN68, enhancing bile tolerance through the bile efflux transporter BmrAB.

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.

The paper introduces a label-free optical imaging method to measure sub-nanometer mechanical motion during action potentials in single mammalian neurons, finding amplitude variations across neurons and regions.

The paper reports the crystal structure of RBBP1's chromo barrel domain and shows it does not bind DNA, contradicting previous reports of DNA-enhanced histone binding.

This study analyzes the quantitative features of HIV-specific CD8+ T-cell responses over acute infection and finds little change in response breadth and no correlation with viral load.