Y. Yang

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study shows that air pollution particles promote lung cancer by hijacking peroxidasin to alter collagen crosslinking, impairing immune surveillance.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

This study shows that N-glycans on Trypanosoma congolense trans-sialidase affect substrate affinity but not conversion rate, with molecular dynamics revealing structural interactions that enhance enzyme function.

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

This paper presents a method using unnatural amino acid-engineered drug-resistant influenza virus to sterilize drug-resistant strains, validated in vitro and in animal models.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

This study uses genome and transcriptome data to analyze phylogenetic relationships in Phrymaceae, finding that major clades remain unresolved despite large-scale data.

This study shows abemaciclib, a CDK4/6 inhibitor, effectively inhibits cell proliferation and induces apoptosis with continuous treatment, outperforming other CDK4/6 inhibitors in breast cancer cell lines.

This study investigates how different polyubiquitin chain lengths and linkages affect UBQLN2's liquid-liquid phase separation, showing that extended chains enhance while compact chains inhibit it.

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

This study investigates the role of viruses in wastewater treatment plants, finding they can enhance contaminant degradation but also spread antibiotic resistance.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

The paper identifies an ER-resident N-acetyltransferase in Plasmodium falciparum essential for parasite growth but not for protein export or acetylation of specific exported proteins.

This paper identifies cell-binding peptides missed in bulk phage display by using emulsion amplification to reduce growth bias in phage libraries.

This study uses single-cell sequencing to identify distinct immune features and CCR6-CCL20 crosstalk in hereditary versus idiopathic chronic pancreatitis.

This study investigates how Aeromonas hydrophila infection affects the metabolomic response and gut microbiota of Charybdis japonica, showing that certain bacteria and metabolites help resist infection.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study shows intermittent fasting induces rapid hepatocyte proliferation in mice to maintain liver-to-body-mass ratio, challenging the view that liver tissue is quiescent unless injured.

This study shows that CBF genes regulate COOLAIR expression during vernalization in Arabidopsis, but COOLAIR is not essential for the vernalization response.

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

This paper identifies Slr0201 in Synechocystis as a protein involved in succinate dehydrogenase-mediated cyclic electron transfer around PSI, based on phenotypic similarities to sdhB mutants.

The paper investigates how mutations at position B18 in proinsulin affect protein foldability and stability, correlating these effects with the age of diabetes onset in mutant proinsulin syndrome.

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

The paper investigates the hybrid origin of C2 photosynthesis in Salsola divaricata agg. by analyzing gene expression and phylogenetic patterns across populations in different habitats.

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.