Y. Zhang

The paper evaluates a new qPCR curve analysis method, CqMAN, against existing approaches using clinical and dilution datasets, showing it is comparable and suitable for qPCR data processing.

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

This study develops a novel mouse model of ovarian granulosa cell tumor-induced cachexia, revealing stage-specific muscle wasting mechanisms and potential therapeutic targets.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

This study improves colorimetric LAMP's speed and sensitivity using guanidine chloride and combined primer sets for better SARS-CoV-2 detection.

This study shows that the pyruvate dehydrogenase complex (PDC) is salt-labile and structurally variable, with activity affected by ionic strength.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper introduces SDsSMLM, a spectroscopic single-molecule localization microscopy technique that improves spatial and spectral precision by symmetrically dispersing photons.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

The paper uses GC content to infer recombination patterns in guppy chromosomes, finding high recombination rates near chromosome ends and no evidence of distinct XY recombination patterns.

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study identifies intrinsic and extrinsic factors that drive increased basal activity of pharyngeal satellite cells compared to limb muscle satellite cells.

This paper develops an electronic blood vessel using flexible bio-degradable circuitry to enhance endothelization and enable gene delivery, showing good biocompatibility and patency in a rabbit model.

This study identifies Adenine Nucleotide Translocase (ANT) as a protective factor against cigarette smoke in lung cells, showing its role in mitochondrial metabolism, airway hydration, and ciliary function in COPD.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study identifies cathepsin B as a protease with unexpected ligase activity, showing it can both cleave and join peptides through a two-step mechanism.