Y. Zhang

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

This study conducts a meta-analysis of 12 articles to evaluate the protective effect of FMDV VP1 protein on animals, finding a significant protective effect with a combined effect value of -0.66.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

The paper identifies five ABCB transporters that regulate lateral root spacing in Arabidopsis by modulating auxin oscillation amplitude in outer root tissues.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

The paper optimizes an automated high-throughput method for isolating cell-free mitochondrial and nuclear DNA from plasma, achieving 6-fold higher yields of mitochondrial DNA.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This study shows that suppressing IL-10 enhances T-cell antitumor activity and improves responses to checkpoint blockade in CLL.

This study shows that acute depletion of GRASP55 or GRASP65 does not affect the Golgi ribbon, but chronic degradation of GRASP55 disrupts its lateral connectivity.

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

This paper identifies UGT76B1 as a glycosyltransferase critical for plant immunity by regulating N-hydroxy-pipecolic acid homeostasis, linking its metabolism to defense and growth trade-offs.

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

The paper investigates how nitrogen availability modulates root growth by fine-tuning polar auxin transport through post-translational modifications of PIN2 and presents a computational model to simulate these processes.

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.