Y. Zhang

This study reveals hidden research bias in urothelial carcinoma cell lines due to driver gene loss from random mutation, suggesting next-generation sequencing is needed and conditionally reprogrammed cells may be a better alternative.

This paper introduces a fluorogenic DNA-PAINT probe that reduces background and increases imaging speed for 3D whole-cell DNA-PAINT.

The paper identifies NAD-RNAs in yeast, showing they are abundant, short, and guarded by decapping enzymes, with in vitro evidence of translational rejection.

This study identifies CAF1 and HIRA as host histone chaperones essential for maintaining Epstein-Barr virus latency by restricting lytic reactivation in Burkitt cells.

The paper identifies and analyzes MATE transporter genes in wild chickpea species under aluminum stress, finding that CaMATE2 is upregulated in all lines while CaMATE1 is upregulated in most, correlating with root growth responses.

The paper introduces a hybrid workflow combining subtomogram averaging and single-particle cryoEM to improve resolution in structural determination, achieving subnanometer resolution for tobacco mosaic virus and RyR1 ion channel.

This study investigates how environmental factors affect lipid cyclization in Sulfolobus acidocaldarius, finding that growth rate correlates with cyclization and suggesting energy availability as a universal driver.

This study identifies high mannose as a key mediator of influenza severity through glycomic analysis in a ferret model.

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

The paper studies the dynamics and morphology of active-passive interfaces in swarming bacteria, finding unique surface roughness and growth exponents influenced by hydrodynamic and steric interactions.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This study evaluates the toxicity of miR-874 antagomiR and miR-146a in cardiomyocytes and cardiac fibroblasts, finding no significant effects on caspase activity or Ca2+ levels but potential impacts on MMP9 expression.

The paper identifies miR-1253 regulation of WAVE2 in AA women with hypertension, linking it to endothelial cell shape and actin cytoskeleton function, and suggests its relevance to health disparities in hypertension.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

A computational method expands the structure space of designer proteins by systematically sampling loop-helix-loop geometries.

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

This paper introduces a HiBiT-based luciferase assay for rapid and accurate quantification of HIV-1 production, outperforming traditional methods like ELISA.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.

This study identifies two distinct mechanisms by which MARCH8 inhibits viral infection: ubiquitination of VSV-G and tyrosine motif-dependent sorting of HIV-1 Env.

The paper shows astrocytes have a translational response to neuronal activity, altering their proteome at synapses through BDNF and K+ signals.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

The paper compares embolism resistance between root and stem xylem in three woody angiosperms, finding roots are more resistant in some species but not all.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

This study shows that PML is required for ALT by localizing the BTR complex to telomeres, and that BTR localization alone can sustain ALT activity.