Y. Zhang

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.

The paper identifies structural determinants of persulfide-sensing specificity in SqrR, showing that structural frustration of the disulfide form enhances tetrasulfide bridge formation and persulfide selectivity.

This study identifies a unique 'fore-mid' four-legged walking pattern in Xya sichuanensis, highlighting physiological and behavioral adaptations for survival in its environment.

This study characterizes an obese ZSF1 rat model of cardiometabolic syndrome and shows that GDF15 treatment reduces metabolic markers and improves cardiac function.

The paper develops a method to improve 4Pi single-molecule localization microscopy by fitting an experimental PSF model, achieving the theoretical resolution limit.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

This study clones and expresses the pig ACE2 gene in a prokaryotic system, produces a polyclonal antibody, and confirms ACE2 expression across pig tissues.

This paper analyzes ancient Y chromosome data to support the Asia origin model for modern human paternal lineages over the African origin model.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

The paper quantifies DNA methylation turnover in mouse pluripotent cells, revealing active oxidation-dependent and -independent processes in formative and primed states.

The paper develops genetically encoded biosensors for isobutanol and isopentanol in yeast to enhance metabolic pathway engineering and strain development.

This study shows that EYA and TIM regulate seasonal physiology in Drosophila by integrating photoperiod and temperature cues to control reproductive dormancy.

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

This study investigates the interaction between invadopodia and the extracellular matrix, showing that Tks5 is involved in matrix-dependent growth and invadopodia formation.

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

This study shows that Tomato spotted wilt virus extends the developmental time and increases progeny production in western flower thrips, with a male-biased sex ratio, likely enhancing virus transmission.

This study presents the structures of human KCC2 and KCC3, including phosphorylation and inhibitor-bound forms, revealing mechanisms of regulation and potential drug targets.

This study determines the cryo-EM structure of human ACE2 bound to the RBD of 2019-nCoV, revealing key interactions and differences compared to SARS-CoV.

The paper presents the cryo-EM structure of human ACE2 in complex with B0AT1, revealing dimeric conformations and potential binding sites for SARS-CoV spike proteins.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

This study shows that hnRNP-U is essential for physiological skeletal muscle hypertrophy, as its deficiency leads to muscle wasting due to impaired autophagy and anabolic resistance.

The paper identifies potential immune targets for 2019-nCoV using sequence homology and bioinformatic predictions.

The paper investigates exosome-mediated apoptosis during WSSV infection in mud crabs, identifying miR-137 and miR-7847 as negative regulators of apoptosis by targeting AIF.

The paper withdraws its manuscript due to invalid results and intends to revise the technical approach and interpretation.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

The paper was withdrawn due to lack of full author consent and is not intended for citation.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.